CAS 206873-63-4

Tariquidar

Description:

Tariquidar is a chemical compound primarily known for its role as a P-glycoprotein (P-gp) inhibitor, which is significant in pharmacology for its potential to enhance the bioavailability of various drugs by preventing their efflux from cells. It is classified as a member of the quinoline family and exhibits a complex structure that contributes to its biological activity. Tariquidar is often studied in the context of cancer therapy, as it may help overcome multidrug resistance in tumor cells by inhibiting the action of P-glycoprotein, a membrane transporter that expels drugs from cells. The compound is typically characterized by its moderate lipophilicity, which influences its absorption and distribution in biological systems. Additionally, it has been evaluated for its safety and efficacy in clinical settings, particularly in combination with other therapeutic agents. Overall, Tariquidar represents a valuable tool in the ongoing research aimed at improving drug delivery and effectiveness in treating various diseases.

Formula: C₃₈H₃₈N₄O₆

InChI: InChI=1S/C38H38N4O6/c1-45-33-18-25-14-16-42(23-28(25)19-34(33)46-2)15-13-24-9-11-29(12-10-24)40-38(44)30-20-35(47-3)36(48-4)21-32(30)41-37(43)27-17-26-7-5-6-8-31(26)39-22-27/h5-12,17-22H,13-16,23H2,1-4H3,(H,40,44)(H,41,43)

InChI key: InChIKey=LGGHDPFKSSRQNS-UHFFFAOYSA-N

SMILES: N(C(=O)C1=CC2=C(N=C1)C=CC=C2)C3=C(C(NC4=CC=C(CCN5CC=6C(CC5)=CC(OC)=C(OC)C6)C=C4)=O)C=C(OC)C(OC)=C3

Synonyms:

• 3-Quinolinecarboxamide, N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-
• N-[2-({4-[2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl]phenyl}carbamoyl)-4,5-dimethoxyphenyl]quinoline-3-carboxamide
• N-[2-[[4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide
• N-[2-[[[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-3-quinolinecarboxamide
• Xr 9576
• Tariquidar

3-Quinolinecarboxamide, N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-

CAS: 206873-63-4

Formula: C₃₈H₃₈N₄O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 646.7315

Ref: IN-DA002IQ5

Tariquidar

CAS: 206873-63-4

Tariquidar

Purity: ≥98%

Molecular weight: 646.73g/mol

Ref: 54-BUP06007

Tariquidar

CAS: 206873-63-4

Formula: C₃₈H₃₈N₄O₆

Purity: ≥ 98.0%

Color and Shape: White powder

Molecular weight: 646.73

Ref: 7W-GP9880

Tariquidar

CAS: 206873-63-4

Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.

Formula: C₃₈H₃₈N₄O₆

Purity: 98.07% - 99.45%

Color and Shape: Solid

Molecular weight: 646.73

Ref: TM-T6287

Tariquidar-d4

Controlled Product

CAS: 206873-63-4

Formula: C₃₈D₄H₃₄N₄O₆

Color and Shape: Neat

Molecular weight: 650.756

Ref: TR-T007602

Tariquidar

CAS: 206873-63-4

Potent P-glycoprotein (P-gp) inhibitor

Formula: C₃₈H₃₈N₄O₆

Purity: Min. 97 Area-%

Color and Shape: Powder

Molecular weight: 646.73 g/mol

Ref: 3D-FT46245