CAS 2070009-72-0

Monomethylauristatin E-d8

CAS: 2070009-72-0

Formula: C₃₉H₅₉D₈N₅O₇

Color and Shape: White To Off-White Solid

Molecular weight: 726.04

Ref: 4Z-PA-329002

D8-MMAE

CAS: 2070009-72-0

D8-MMAE is a chemical conjugate product, which is composed of the highly potent cytotoxic agent monomethyl auristatin E (MMAE) linked to targeting moieties, often through a stable linker. This product is synthetic in origin, derived from auristatins, which are analogs of dolastatin 10, a natural peptide isolated from marine organisms. The mode of action of D8-MMAE involves specific binding to cellular targets, typically through an antibody-drug conjugate (ADC) mechanism, where the conjugate binds to antigens on cancer cells. Once internalized, the linker is cleaved, releasing MMAE within the cell. MMAE then binds to tubulin, inhibiting cell division by disrupting the microtubule network, leading to apoptosis.

Formula: C₃₉H₆₇N₅O₇

Purity: Min. 95%

Molecular weight: 726 g/mol

Ref: 3D-VHD00972

MMAE-d8

CAS: 2070009-72-0

MMAE-d8 is a deuterated compound of MMAE (Monomethyl Auristatin), suitable for isotope tracing. MMAE is a tubulin microtubule inhibitor.

Formula: C₃₉H₅₉D₈N₅O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 726.03

Ref: TM-T10948