CAS 2070014-82-1

2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-, compd. with methanesulfonate (1:2)

Description:

2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-, compd. with methanesulfonate (1:2) is a complex organic compound characterized by its amide functional group and multiple substituents that contribute to its biological activity. The presence of a methanesulfonate salt indicates that it is likely soluble in polar solvents, enhancing its bioavailability. The compound features a dimethylamino group, which can influence its pharmacological properties, potentially enhancing its interaction with biological targets. Additionally, the indole and pyrimidine moieties suggest potential applications in medicinal chemistry, particularly in the development of pharmaceuticals. The methoxy group may also play a role in modulating the compound's electronic properties and steric hindrance. Overall, this compound's intricate structure suggests it may exhibit significant biological activity, warranting further investigation in drug development and therapeutic applications.

Formula: C₂₉H₃₇N₇O₅S

InChI: InChI=1S/C28H33N7O2.CH4O3S/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24;1-5(2,3)4/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32);1H3,(H,2,3,4)

InChI key: InChIKey=FUKSNUHSJBTCFJ-UHFFFAOYSA-N

SMILES: CN1C=C(C=2C1=CC=CC2)C3=NC(NC4=C(OC)C=C(N(CCN(C)C)C)C(NC(C=C)=O)=C4)=NC=C3.S(C)(=O)(=O)O

Synonyms:

• AZD 9291 dimesylate
• AZD-9291 dimesylate
• AZD9291 dimesylate
• 2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-, compd. with methanesulfonate (1:2)
• Osimertinib dimesylate

Osimertinib dimesylate

CAS: 2070014-82-1

Osimertinib dimesylate

Purity: ≥98%

Molecular weight: 691.82g/mol

Ref: 54-BUP22196

Osimertinib dimesylate

CAS: 2070014-82-1

Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor (IC50s: 12 and 1 nM against EGFR L858R and EGFR L858R/T790M).

Formula: C₃₀H₄₁N₇O₈S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 691.82

Ref: TM-T10433