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CAS 2071196-10-4

:

TQ05310

Formula:C19H17F6N7O
Synonyms:
  • 1,3,5-Triazine-2,4-diamine, N2-(1,1-dimethylethoxy)-N4-[2-(trifluoromethyl)-4-pyridinyl]-6-[6-(trifluoromethyl)-2-pyridinyl]-
  • TQ05310
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    TQ05310

    CAS:
    TQ05310 is an orally active inhibitor of mutant IDH2, targeting both IDH2-R140Q (IC50=136.9 nM) and IDH2-R172K (IC50=37.9 nM) mutations. This compound suppresses the production of 2-hydroxyglutarate (2-HG) by inhibiting the enzymatic activity of mutant IDH2, and induces differentiation in cells expressing IDH2-R140Q and IDH2-R172K. TQ05310 is utilized in research on acute myeloid leukemia.
    Formula:C19H17F6N7O
    Molecular weight:473.38

    Ref: TM-T89839