CAS 207399-07-3

IR 780

Description:

IR 780, with the CAS number 207399-07-3, is a near-infrared (NIR) fluorescent dye that is primarily used in biological imaging and photothermal therapy applications. This compound exhibits strong absorption in the near-infrared region, which allows for deeper tissue penetration and reduced background fluorescence, making it particularly useful in medical diagnostics and research. IR 780 is characterized by its high photostability and low toxicity, which are essential for in vivo imaging. Additionally, it has been studied for its potential in targeted drug delivery systems due to its ability to selectively accumulate in certain types of cancer cells. The dye's unique properties enable it to serve as a valuable tool in both fundamental research and clinical applications, particularly in the fields of oncology and molecular imaging. Overall, IR 780 represents a significant advancement in the development of imaging agents that can enhance the visualization of biological processes in real-time.

Formula: C₃₆H₄₄ClN₂·I

InChI: InChI=1S/C36H44ClN2.HI/c1-7-24-38-30-18-11-9-16-28(30)35(3,4)32(38)22-20-26-14-13-15-27(34(26)37)21-23-33-36(5,6)29-17-10-12-19-31(29)39(33)25-8-2;/h9-12,16-23H,7-8,13-15,24-25H2,1-6H3;1H/q+1;/p-1

InChI key: InChIKey=IRPKBYJYVJOQHQ-UHFFFAOYSA-M

SMILES: C(CC)N1C=2C(C(C)(C)C1=CC=C3C(Cl)=C(C=CC4=[N+](CCC)C=5C(C4(C)C)=CC=CC5)CCC3)=CC=CC2.[I-]

Synonyms:

• 2-[(Z)-2-{(3E)-2-chloro-3-[(2E)-2-(3,3-dimethyl-1-propyl-1,3-dihydro-2H-indol-2-ylidene)ethylidene]cyclohex-1-en-1-yl}ethenyl]-3,3-dimethyl-1-propyl-3H-indolium iodide
• 3H-Indolium, 2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propyl-, iodide
• 3H-Indolium, 2-(2-(2-chloro-3-(2-(1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propyl-, iodide (1:1)
• Ads 775Pi
• Ir 780
• IR 780 iodide

11-Chloro-1,1'-di-n-propyl-3,3,3',3'-tetramethyl-10,12-trimethyleneindatricarbocyanine iodide, 95%

CAS: 207399-07-3

11-Chloro-1,1'-di-n-propyl-3,3,3',3'-tetramethyl-10,12-trimethyleneindatricarbocyanine iodide is used as a laser and IR dye. It is also used as lithographic computer to plate laser applications. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. S

Formula: C₃₆H₄₄ClIN₂

Purity: 95%

Color and Shape: Green/gold to dark green, Crystals or crystalline powder

Molecular weight: 667.12

Ref: 02-H32150

3H-Indolium,2-[2-[2-chloro-3-[(1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene]-1-cyclohexen-1-yl]ethenyl]-3,3-dimethyl-1-propyl-, iodide

CAS: 207399-07-3

Formula: C₃₆H₄₄ClIN₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 667.1054

Ref: IN-DA01FL1R

IR-780 Iodide

CAS: 207399-07-3

IR-780 Iodide

Purity: ≥98%

Molecular weight: 667.12g/mol

Ref: 54-BUP11850

11-Chloro-1,1’-Di-N-Propyl-3,3,3’,3’-Tetramethyl-10,12-Trimethyleneindatricarbocyanine Iodide

CAS: 207399-07-3

11-Chloro-1,1’-Di-N-Propyl-3,3,3’,3’-Tetramethyl-10,12-Trimethyleneindatricarbocyanine Iodide

Purity: 98%

Molecular weight: 667.11g/mol

Ref: 54-OR1009322

IR 780

CAS: 207399-07-3

Formula: C₃₆H₄₄ClIN₂

Purity: >95.0%(HPLC)(qNMR)

Color and Shape: Yellow to Brown to Dark green powder to crystal

Molecular weight: 667.12

Ref: 3B-I1281

IR-780 Iodide

CAS: 207399-07-3

IR-780 Iodide: a near-infrared dye for HIF-1α/glycolysis ABCB10-dependent human CSC characterization.

Formula: C₃₆H₄₄ClIN₂

Purity: 99.98%

Color and Shape: Solid

Molecular weight: 667.12

Ref: TM-T20974

IR-780 iodide

CAS: 207399-07-3

IR-780 iodide is a water-soluble drug that has been shown to have significant cytotoxicity against prostate cancer cells. It binds to the mitochondrial membrane potential, which is involved in energy production and the regulation of the cell cycle. IR-780 iodide is taken up by tumor cells, where it inhibits adriamycin uptake and induces apoptosis. In vitro assays have shown that IR-780 iodide can be used as a diagnostic tool for detecting bladder cancer by binding to the mitochondria of cells from patients with bladder cancer. In vivo studies have been done in mice to determine the effectiveness of IR-780 iodide in treating cervical cancer. These studies showed that IR-780 iodide was not significantly effective in vivo, due to its low bioavailability and lack of specificity for cervical cancer cells. Histological analysis showed that IR-780 iodide did not inhibit tumor growth or induce apoptosis in vivo.

Formula: C₃₆H₄₄ClIN₂

Purity: Min. 95%

Molecular weight: 667.11 g/mol

Ref: 3D-HIA39907