CAS 207679-81-0

5-Hydroxymethyltolterodine

Description:

5-Hydroxymethyltolterodine is a chemical compound that serves as a metabolite of tolterodine, which is primarily used in the treatment of overactive bladder. This substance is characterized by its structural features, including a hydroxymethyl group and a tolterodine backbone, which contribute to its pharmacological properties. It is typically classified as an antimuscarinic agent, functioning by inhibiting the action of acetylcholine on muscarinic receptors in the bladder, thereby reducing involuntary contractions. The compound is soluble in organic solvents and exhibits moderate stability under standard conditions. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are influenced by its chemical structure, which affects its interaction with biological systems. Research into 5-Hydroxymethyltolterodine has provided insights into its efficacy and safety profile, making it a subject of interest in pharmacological studies related to urinary disorders. As with many pharmaceuticals, understanding its characteristics is crucial for optimizing therapeutic applications and minimizing potential side effects.

Formula: C₂₂H₃₁NO₂

InChI: InChI=1S/C22H31NO2/c1-16(2)23(17(3)4)13-12-20(19-8-6-5-7-9-19)21-14-18(15-24)10-11-22(21)25/h5-11,14,16-17,20,24-25H,12-13,15H2,1-4H3/t20-/m1/s1

InChI key: InChIKey=DUXZAXCGJSBGDW-HXUWFJFHSA-N

SMILES: [C@H](CCN(C(C)C)C(C)C)(C1=CC(CO)=CC=C1O)C2=CC=CC=C2

Synonyms:

• (+)-N,N-Diisopropyl-3-(2-hydroxy-5-hydroxymethylphenyl)-3-phenylpropylamine
• (R)-5-Hydroxymethyl tolterodine
• 2-[(1R)-3-[Di(propan-2-yl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenol
• 3-[(1R)-3-[Bis(1-Methylethyl)Amino]-1-Phenylpropyl]-4-Hydroxy-Benzenemethanol
• 3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-hydroxybenzenemethanol
• 5-Hydroxymethyltolterodine
• Benzenemethanol, 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-hydroxy-
• Desfesoterodine
• Pnu 200577
• R-(+)-2(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol
• Spm 7605

Benzenemethanol, 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-hydroxy-

CAS: 207679-81-0

Formula: C₂₂H₃₁NO₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 341.4870

Ref: IN-DA002J79

Desfesoterodine

CAS: 207679-81-0

Desfesoterodine

Purity: ≥98%

Molecular weight: 341.49g/mol

Ref: 54-BUP12820

Desfesoterodine

CAS: 207679-81-0

Desfesoterodine (5-HMT) is a new muscarinic receptor antagonist with Kb of 0.84 nM.

Formula: C₂₂H₃₁NO₂

Purity: 99.77%

Color and Shape: Solid

Molecular weight: 341.49

Ref: TM-T6364

(R)-5-Hydroxymethyl Tolterodine

Controlled Product

CAS: 207679-81-0

Applications A metabolite of Tolterodine (T535800), a muscarinic receptor antagonist used in the treatment of urinary incontinence.
References Palmer, L., et al.: J. Pharm. Biomed. Anal., 16, 155 (1997), Hills, C., et al.: Drugs, 55, 813 (1998), Wefer, J., et al.: World J. Urol., 19, 312 (2001),

Formula: C₂₂H₃₁NO₂

Color and Shape: Neat

Molecular weight: 341.49

Ref: TR-H948363

(R)-5-Hydroxymethyl tolterodine

CAS: 207679-81-0

(R)-5-Hydroxymethyl tolterodine is a prodrug that is metabolized by cytochrome P450 3A4 (CYP3A4) in the liver to its active form, tolterodine. This drug can be used as an alternative for gabapentin in the treatment of detrusor muscle overactivity associated with neurogenic bladder dysfunction. The pharmacokinetic properties of (R)-5-hydroxymethyl tolterodine are similar to those of gabapentin, including the elimination half-life and volume of distribution. However, unlike gabapentin, which has been shown to increase the glomerular filtration rate (GFR) and renal blood flow, there is no evidence that this drug has any effect on GFR or renal blood flow. There is also no evidence that (R)-5-hydroxymethyl tolterodine causes any symptoms that may be attributed to

Formula: C₂₂H₃₁NO₂

Purity: Min. 98 Area-%

Color and Shape: Off-White Powder

Molecular weight: 341.49 g/mol

Ref: 3D-FH24399

Tolterodine Hydroxymethyl Analog

CAS: 207679-81-0

Formula: C₂₂H₃₁NO₂

Molecular weight: 341.49

Ref: ST-EA-CP-T25048

Fesoterodine Impurity 3

CAS: 207679-81-0

Formula: C₂₂H₃₁NO₂

Molecular weight: 341.49

Ref: ST-EA-CP-F17028