PROTAC FKBP Degrader-3 is a small molecule classified as a proteolysis-targeting chimera (PROTAC), designed to selectively degrade specific proteins within cells. This compound operates by harnessing the cellular ubiquitin-proteasome system, linking a target protein to an E3 ubiquitin ligase, which facilitates the ubiquitination and subsequent degradation of the target. The FKBP (FK506-binding protein) component of the molecule serves as a ligand that binds to the target protein, while the other part of the PROTAC interacts with the E3 ligase, creating a ternary complex that promotes the degradation process. Characteristics of PROTAC FKBP Degrader-3 include its potential for high specificity and efficacy in targeting disease-related proteins, making it a promising candidate for therapeutic applications, particularly in cancer and other diseases where protein dysregulation is a factor. Additionally, its design allows for the modulation of protein levels rather than merely inhibiting their function, offering a novel approach to drug development. As with any chemical substance, safety and handling precautions should be observed, and its use should be guided by appropriate research protocols.

PROTAC FKBP Degrader-3

2079056-43-0: PROTAC FKBP Degrader-3 is a small molecule classified as a proteolysis-targeting chimera (PROTAC), designed to selectively degrade specific proteins within cells. This compound operates by harnessing the cellular ubiquitin-proteasome system, linking a target protein to an E3 ubiquitin ligase, which facilitates the ubiquitination and subsequent degradation of the target. The FKBP (FK506-binding protein) component of the molecule serves as a ligand that binds to the target protein, while the other part of the PROTAC interacts with the E3 ligase, creating a ternary complex that promotes the degradation process. Characteristics of PROTAC FKBP Degrader-3 include its potential for high specificity and efficacy in targeting disease-related proteins, making it a promising candidate for therapeutic applications, particularly in cancer and other diseases where protein dysregulation is a factor. Additionally, its design allows for the modulation of protein levels rather than merely inhibiting their function, offering a novel approach to drug development. As with any chemical substance, safety and handling precautions should be observed, and its use should be guided by appropriate research protocols.

<p>PROTAC FKBP Degrader-3, with FKBP and VHL binding groups linked, is a potent FKBP degrader.</p>

CAS 2079056-43-0

PROTAC FKBP Degrader-3

PROTAC FKBP Degrader-3

Ref: TM-T18610