CAS 208538-73-2

Micafungin Sodium

Description:

Micafungin sodium is an antifungal agent belonging to the echinocandin class, primarily used in the treatment of invasive fungal infections, particularly those caused by Candida and Aspergillus species. It functions by inhibiting the synthesis of β-(1,3)-D-glucan, an essential component of the fungal cell wall, thereby compromising the structural integrity of the fungus and leading to cell lysis. Micafungin is typically administered intravenously and is characterized by its broad-spectrum activity against various fungal pathogens, making it a valuable option in clinical settings, especially for immunocompromised patients. The substance is soluble in water and exhibits stability under physiological conditions. Its pharmacokinetics involve a relatively long half-life, allowing for once-daily dosing. Common side effects may include infusion-related reactions, liver enzyme elevations, and gastrointestinal disturbances. Due to its mechanism of action and safety profile, micafungin is often preferred in cases where other antifungal therapies may be less effective or contraindicated.

InChI: InChI=1/C56H71N9O23S.Na/c1-4-5-6-17-86-32-14-11-28(12-15-32)39-21-33(63-87-39)27-7-9-29(10-8-27)49(75)58-34-20-38(70)52(78)62-54(80)45-46(72)25(2)23-65(45)56(82)43(37(69)22-41(57)71)60-53(79)44(48(74)47(73)30-13-16-36(68)40(18-30)88-89(83,84)85)61-51(77)35-19-31(67)24-64(35)55(81)42(26(3)66)59-50(34)76;/h7-16,18,21,25-26,31,34-35,37-38,42-48,52,66-70,72-74,78H,4-6,17,19-20,22-24H2,1-3H3,(H2,57,71)(H,58,75)(H,59,76)(H,60,79)(H,61,77)(H,62,80)(H,83,84,85);/q;+1/p-1/t25-,26-,31+,34?,35-,37+,38+,42-,43-,44-,45-,46-,47+,48?,52-;/m1./s1

SMILES: CCCCCOc1ccc(cc1)c1cc(c2ccc(cc2)C(=O)NC2CC(C(N=C(C3C(C(C)CN3C(=O)C(C(CC(=N)O)O)N=C(C(C(C(c3ccc(c(c3)OS(=O)(=O)O)O)O)O)N=C(C3CC(CN3C(=O)C(C(C)O)N=C2O)O)O)O)O)O)O)O)no1.[Na]

Synonyms:

• Fk 463
• 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((1R)-3-Amino-1-hydroxy-3-oxopropyl)-2,11,12,15-tetrahydroxy-6-((1R)-1-hydroxyethyl)-16-methyl-5,8,14,19,22,25-hexaoxo-9-((4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzoyl)amino)tetracosahydro-1H-dipyrrolo(2,1-c:2',1'-l)(1,4,7,10,13,16)hexaazacyclohenicosin-23-yl)-1,2-dihydroxyethyl)-2-hydroxyphenyl sodium sulfate
• Fk463
• Unii-Is1Up79R56
• Pneumocandin A0, 1-((4R,5R)-4,5-dihydroxy-N2-(4-(5-(5-(pentyloxy)phenyl)-3-isoxazolyl)benzoyl)-L-ornithine)-4-((4S)-4-hydroxy-4-(4-hydroxy-3-(sulfooxy)phenyl)-L-threonine)-, monosodium salt

Micafungin Sodium

CAS: 208538-73-2

Formula: C56H70N9O23SNa

Purity: ≥97% (HPLC)

Color and Shape: white to beige powder

Molecular weight: 1292.26

Ref: 23-SML2268

Micafungin Sodium (INTERNATIONAL COLD SHIPMENT REQUIRED)

CAS: 208538-73-2

Antibiotics nesoi

Formula: C₅₆H₇₀N₉NaO₂₃S

Color and Shape: White Powder

Molecular weight: 1291.4203

Ref: 45-1443384

Pneumocandin A0, 1-[(4R,5R)-4,5-dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]-, sodium salt (1:1)

CAS: 208538-73-2

Formula: C₅₆H₇₀N₉NaO₂₃S

Purity: 97%

Color and Shape: Solid

Molecular weight: 1292.2563

Ref: IN-DA002JQV

Micafungin Sodium Salt

CAS: 208538-73-2

Formula: C₅₆H₇₀N₉O₂₃S·Na

Color and Shape: White To Off-White Solid Solid

Molecular weight: 1269.29 22.99

Ref: 4Z-PM-127001

Micafungin (sodium)

CAS: 208538-73-2

Micafungin (sodium)

Purity: 97%

Molecular weight: 1292.26g/mol

Ref: 54-OR1031626

Micafungin sodium

CAS: 208538-73-2

Formula: C₅₆H₇₁N₉O₂₃S·Na

Purity: ≥ 98.0% (anhydrous)

Color and Shape: White to off-white or beige powder

Molecular weight: 1292.28

Ref: 7W-GX5973

Micafungin sodium

CAS: 208538-73-2

Micafungin sodium (FK 463) is the sodium salt form of micafungin, a semi-synthetic echinocandin derived from a natural product of the fungus Coleophoma empetri

Formula: C₅₆H₇₀N₉NaO₂₃S

Purity: 98% - 99.41%

Color and Shape: Solid

Molecular weight: 1292.26

Ref: TM-T1794

Micafungin Sodium

CAS: 208538-73-2

Stability Hygroscopic
Applications An echinocandin antifungal drug which inhibits the synthesis of 1,3-β-D-glucan, an essential component of the fungal cell wall, and represent a valuable treatment option for fungal infections.
References Chen, S.C. et al.: Drugs, 71, 11 (2011); Groll, A.H. et al.: Opin. Anti-Infect. Invest. Drugs, 2, 405 (2000); Tomishima, M. et al.: J. Antibiot., 52, 674 (1999);

Formula: C₅₆H₇₀N₉O₂₃S·Na

Color and Shape: Off White

Molecular weight: 1292.26

Ref: TR-M342350

Micafungin sodium

CAS: 208538-73-2

Anti-fungal; glucan synthase inhibitor

Formula: C₅₆H₇₀N₉NaO₂₃S

Purity: Min. 97 Area-%

Color and Shape: White Powder

Molecular weight: 1,292.26 g/mol

Ref: 3D-FM34148

Micafungin-¹³C₆ Sodium

Controlled Product

CAS: 208538-73-2

Formula: C₅₀C₆H₇₀N₉NaO₂₃S

Color and Shape: Neat

Molecular weight: 1298.22

Ref: TR-M442141

Micafungin-d11 Sodium

Controlled Product

CAS: 208538-73-2

Applications Micafungin-d11 Sodium is the isotope labelled analog of Micafungin Sodium (M342350); an echinocandin antifungal drug which inhibits the synthesis of 1,3-β-D-glucan, an essential component of the fungal cell wall. Micafungin Sodium also represents a valuable treatment option for fungal infections.
References Chen, S.C. et al.: Drugs, 71, 11 (2011); Groll, A.H. et al.: Opin. Anti-Infect. Invest. Drugs, 2, 405 (2000); Tomishima, M. et al.: J. Antibiot., 52, 674 (1999)

Formula: C₅₆H₅₉D₁₁N₉NaO₂₃S

Color and Shape: Neat

Molecular weight: 1303.33

Ref: TR-M342352

Micafungin sodium - Bio-X ™

CAS: 208538-73-2

Micafungin, as one of three echinocandina, has been proven to be a successful antifungal therapeutic in treating general Candida fungus infections. The treatment of immunocompromised patients is particularly important as Candida infections cause high mortality rates in patients in intensive care units, receiving chemotherapy, or stem cell transplants. This product acts as an anti-fungal by inhibiting the 1,3-beta-D-glucan synthase enzyme. As a result the production of 1,3-beta-D-glucan, which is crucial to the fungal cell wall, is hindered. Thus, the fungal cell wall loses integrity allowing for osmotic instability and cell lysis to occur.

Formula: C₅₆H₇₁N₉O₂₃S•Na

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,293.27 g/mol

Ref: 3D-BM164667