CAS 2086300-61-8
:PROTAC BRD4 Degrader-20
Description:
PROTAC BRD4 Degrader-20 is a small molecule designed as a targeted protein degrader, specifically aimed at the bromodomain-containing protein 4 (BRD4). This compound belongs to a class of molecules known as PROTACs (Proteolysis Targeting Chimeras), which harness the cell's ubiquitin-proteasome system to selectively degrade target proteins. The structure of PROTAC BRD4 Degrader-20 typically includes a ligand that binds to BRD4, linked to another ligand that recruits an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent degradation of BRD4. This mechanism allows for the modulation of protein levels in a highly specific manner, making it a valuable tool in research and potential therapeutic applications, particularly in cancer treatment where BRD4 is implicated in oncogenic processes. The compound's efficacy, selectivity, and pharmacokinetic properties are critical for its development as a therapeutic agent, and ongoing studies aim to elucidate its biological effects and optimize its use in clinical settings.
- PROTAC BRD4 Degrader-20
- (2S,4R)-1-[(2S)-3,3-dimethyl-2-({5-[(1s,3s)-3-{2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.02,?]trideca-2(6),4,7,10,12-pentaen-9-yl]acetamido}cyclobutoxy]-1-benzofuran-2-yl}formamido)butanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
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PROTAC BRD4 Degrader-20
CAS:<p>PROTAC BRD4 Degrader-20 (compound 195) is a bifunctional degrader of BRD4 [1].</p>Formula:C55H58ClN9O7S2Color and Shape:SolidMolecular weight:1056.69
