CAS 208762-35-0

Abacavir EP Impurity E

CAS: 208762-35-0

Formula: C₁₄H₂₀N₆O

Molecular weight: 288.36

Ref: 4Z-A-2816

[(1R,3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentyl]methanol

CAS: 208762-35-0

Color and Shape: Neat

Ref: 86-MM3249.10

(1R,3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentanemethanol

Controlled Product

CAS: 208762-35-0

Impurity Abacavir EP Impurity E
Applications (1R,3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentanemethanol (Abacavir EP Impurity E) is an impurity of Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)

Formula: C₁₄H₂₀N₆O

Color and Shape: White Solid

Molecular weight: 288.35

Ref: TR-A603795

(1R,3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentanemethanol-d4

Controlled Product

CAS: 208762-35-0

Formula: C₁₄D₄H₁₆N₆O

Color and Shape: Neat

Molecular weight: 292.373

Ref: TR-A603797

Abacavir Impurity E

CAS: 208762-35-0

Abacavir impurity E is a crystalline solid that has been identified as an impurity present in abacavir. It exhibits affinity for the receptor and can be used to treat inflammatory diseases, neurodegenerative diseases, and other disorders. Abacavir impurity E binds to the receptor by binding to the zinc ion, which is a part of the zinc-binding site of the receptor. This binding leads to activation of the receptor and subsequent reactions. Abacavir impurity E is also known to exhibit anti-inflammatory properties. The molecular weight of this substance is 643 g/mol, with a signal at m/z 54, which corresponds to C18H25NO3. The chemical formula for this substance is CH3(CH2)2N(CH3)2COOH.

Formula: C₁₄H₂₀N₆O·C₄H₆O₄

Purity: Min. 95%

Molecular weight: 406.44 g/mol

Ref: 3D-IIA76235

Abacavir EP Impurity E

CAS: 208762-35-0

Formula: C₁₄H₂₀N₆O

Molecular weight: 288.4

Ref: ST-EA-CP-A1005