CAS 208848-19-5

2-(5-Amino-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-yl)-N-[1-(5-tert-butyl-1,3,4-oxadiazol-2-ycarbonyl)-2-methylpropyl]acetamide

Description:

The chemical substance known as "2-(5-Amino-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-yl)-N-[1-(5-tert-butyl-1,3,4-oxadiazol-2-ycarbonyl)-2-methylpropyl]acetamide," with the CAS number 208848-19-5, is a complex organic compound characterized by its multi-functional structure. It features a dihydropyrimidine core, which is known for its role in various biological activities, including potential therapeutic applications. The presence of an amino group and a carbonyl moiety suggests that it may participate in hydrogen bonding, influencing its solubility and reactivity. Additionally, the tert-butyl and phenyl groups contribute to its hydrophobic characteristics, which can affect its interaction with biological membranes. The oxadiazole moiety is often associated with bioactivity, potentially enhancing the compound's pharmacological properties. Overall, this compound's unique structural features may provide avenues for research in medicinal chemistry, particularly in the development of new pharmaceuticals targeting specific biological pathways.

Formula: C₂₃H₂₈N₆O₄

InChI: InChI=1/C23H28N6O4/c1-13(2)17(18(31)20-27-28-22(33-20)23(3,4)5)26-16(30)12-29-19(14-9-7-6-8-10-14)25-11-15(24)21(29)32/h6-11,13,17H,12,24H2,1-5H3,(H,26,30)

SMILES: CC(C)C(C(=O)c1nnc(C(C)(C)C)o1)N=C(Cn1c(c2ccccc2)ncc(c1=O)N)O

Synonyms:

• Freselestat
• Ono-Po-736
• Ono-6818
• 2-(5-amino-6-oxo-2-phenylpyrimidin-1(6H)-yl)-N-[1-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-3-methyl-1-oxobutan-2-yl]acetamide
• Freselesat
• 1(6H)-PyriMidineacetaMide,5-aMino-N-[1-[[5-(1,1-diMethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-Methylpropyl]-6-oxo-2-phenyl-
• ONO6818
• 5-Amino-N-[1-[[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-methylpropyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetamide

1(6H)-Pyrimidineacetamide, 5-amino-N-[1-[[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-methylpropyl]-6-oxo-2-phenyl-

CAS: 208848-19-5

Formula: C₂₃H₂₈N₆O₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 452.5062

Ref: IN-DA002JX0

Freselestat

Controlled Product

CAS: 208848-19-5

Applications Freselestat is a highly potent nonpeptidic orally active inhibitor of human neutrophil elastase (HNE) and can be used as treatment for neutrophil-predominant inflammatory lung diseases.
References Ohbayashi, H.: IDrugs, 5, 910 (2002); Trifilieff, A.: Curr. Opin. Invest. Dr., 3, 1161 (2002); Ohmoto, K., et al.: Synlett, no vol., 299 (2001); Ohmoto, K., et al.: J. Med. Chem., 43, 4927 (2000)

Formula: C₂₃H₂₈N₆O₄

Color and Shape: Neat

Molecular weight: 452.51

Ref: TR-F764500

Freselestat

CAS: 208848-19-5

Freselestat (ONO-6818) inhibits neutrophil elastase, reduces interleukin 8, C5B-9, and inflammation in cardiopulmonary bypass.

Formula: C₂₃H₂₈N₆O₄

Color and Shape: Solid

Molecular weight: 452.51

Ref: TM-T31877