CAS 2089721-94-6

2-Propenamide, N-[3-[[2-[[2-methoxy-6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-

Description:

2-Propenamide, N-[3-[[2-[[2-methoxy-6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]- is a complex organic compound characterized by its multi-functional structure, which includes an amide group and various aromatic and heterocyclic moieties. The presence of a trifluoromethyl group enhances its lipophilicity and may influence its biological activity. The compound also features a methoxy group and a piperazine ring, which are often associated with pharmacological properties, potentially making it a candidate for drug development. Its molecular structure suggests it may interact with biological targets, possibly in the context of cancer or other diseases, given the presence of pyrimidine and pyridine rings, which are common in medicinal chemistry. The compound's solubility, stability, and reactivity would depend on its specific functional groups and overall molecular conformation. As with many synthetic organic compounds, safety and handling precautions are essential due to potential toxicity or reactivity.

Formula: C₂₅H₂₇F₃N₈O₂

Synonyms:

• 2-Propenamide, N-[3-[[2-[[2-methoxy-6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-

ES-072

CAS: 2089721-94-6

ES-072, a selective inhibitor targeting the EGFR mutant (EGFR-T790M), is administered orally. By hindering EGFR-T790M activity, it activates GSK3α, which subsequently leads to the phosphorylation of PD-L1 at Ser279 and Ser283. This phosphorylation facilitates the recruitment of the E3 ubiquitin ligase ARIH1, resulting in the ubiquitination and proteasomal degradation of PD-L1. Such a process not only curtails the growth of cancer cells but also amplifies the anti-tumor immune response by diminishing PD-L1 levels. ES-072 has shown efficacy in impeding the proliferation of non-small cell lung cancer (NSCLC) cells.

Formula: C₂₅H₂₇F₃N₈O₂

Color and Shape: Solid

Molecular weight: 528.53

Ref: TM-T200087