CAS 208993-54-8

Fiduxosin

Description:

Fiduxosin is a chemical compound classified as a selective antagonist of the alpha-1 adrenergic receptor, primarily used in the treatment of benign prostatic hyperplasia (BPH). It functions by relaxing the smooth muscles in the prostate and bladder neck, thereby improving urinary flow and reducing symptoms associated with BPH. The molecular structure of fiduxosin includes a piperidine ring, which contributes to its pharmacological activity. It exhibits a favorable pharmacokinetic profile, with good oral bioavailability and a moderate half-life, allowing for once-daily dosing. Additionally, fiduxosin has been studied for its potential effects on cardiovascular parameters, although it is primarily focused on urological applications. As with many medications, potential side effects may include dizziness, fatigue, and orthostatic hypotension, particularly upon initiation of therapy. Overall, fiduxosin represents a targeted approach in managing urinary symptoms related to prostate enlargement, with ongoing research into its broader therapeutic implications.

Formula: C₃₀H₂₉N₅O₄S

InChI: InChI=1S/C30H29N5O4S/c1-38-22-10-7-11-23-24(22)20-16-34(15-19(20)17-39-23)12-5-6-13-35-29(36)27-25(33-30(35)37)26-28(40-27)31-14-21(32-26)18-8-3-2-4-9-18/h2-4,7-11,14,19-20H,5-6,12-13,15-17H2,1H3,(H,33,37)/t19-,20-/m1/s1

InChI key: InChIKey=WDTAYDBPNYFWDR-WOJBJXKFSA-N

SMILES: O=C1C2=C(C=3C(S2)=NC=C(N3)C4=CC=CC=C4)NC(=O)N1CCCCN5C[C@@]6([C@](C5)(COC=7C6=C(OC)C=CC7)[H])[H]

Synonyms:

• 8-Phenyl-3-[4-[(3aR,9bR)-1,3a,4,9b-tetrahydro-9-methoxy[1]benzopyrano[3,4-c]pyrrol-2(3H)-yl]butyl]pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
• 8-Phenyl-3-[4-[(3aR,9bR)-1,3a,4,9b-tetrahydro-9-methoxy[1]benzopyrano[3,4-c]pyrrol-2(3H)-yl]butyl]pyrazino[2′,3′:4,5]thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
• Fiduxosin
• Pyrazino[2′,3′:4,5]thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione, 8-phenyl-3-[4-[(3aR,9bR)-1,3a,4,9b-tetrahydro-9-methoxy[1]benzopyrano[3,4-c]pyrrol-2(3H)-yl]butyl]-
• pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione, 8-phenyl-3-[4-[(3aR,9bR)-1,3a,4,9b-tetrahydro-9-methoxy[1]benzopyrano[3,4-c]pyrrol-2(3H)-yl]butyl]-

Fiduxosin

Controlled Product

CAS: 208993-54-8

Formula: C₃₀H₂₉N₅O₄S

Color and Shape: Neat

Molecular weight: 555.647

Ref: TR-F335540

Fiduxosin-d6

Controlled Product

CAS: 208993-54-8

Formula: C₃₀H₂₃D₆N₅O₄S

Color and Shape: Neat

Molecular weight: 375.44

Ref: TR-F335542

Fiduxosin

CAS: 208993-54-8

Fiduxosin is a peptide that belongs to the class of ligands, which are small molecules that bind to and activate receptors. Fiduxosin binds to and activates the protein ion channels, which are responsible for maintaining the membrane potential of cells. It has been shown to inhibit the activity of phospholipase A2, an enzyme that is involved in inflammation. Fiduxosin also binds to and activates the protein receptor known as Ligand-gated ion channels (LGICs), which are associated with pain transmission. LGICs are activated by GABA, a neurotransmitter involved in regulating pain sensitivity. Fiduxosin may be used as a research tool to study how peptides interact with proteins or antibodies.

Formula: C₃₀H₂₉N₅O₄S

Purity: Min. 95%

Molecular weight: 555.6 g/mol

Ref: 3D-IIA99354

Fiduxosin

CAS: 208993-54-8

Fiduxosin is a selective and potent α1-adrenoceptor antagonist with inhibitory effects on α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, with Ki

Formula: C₃₀H₂₉N₅O₄S

Purity: 99.73%

Color and Shape: Solid

Molecular weight: 555.65

Ref: TM-T11286