CAS 209342-40-5

Finafloxacin

Description:

Finafloxacin is a synthetic fluoroquinolone antibiotic characterized by its broad-spectrum antibacterial activity, particularly against Gram-negative and some Gram-positive bacteria. It is known for its unique mechanism of action, which involves inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for bacterial DNA replication and repair. Finafloxacin exhibits improved efficacy in acidic environments, making it particularly effective in treating infections in conditions such as otitis externa and other localized infections. The compound is typically administered topically and is notable for its favorable pharmacokinetic profile, which includes rapid absorption and distribution in tissues. Additionally, it has a relatively low potential for developing bacterial resistance compared to other antibiotics in its class. Its chemical structure includes a bicyclic core with various substituents that contribute to its antibacterial properties. As with any antibiotic, appropriate use is essential to minimize the risk of resistance development and ensure effective treatment outcomes.

Formula: C₂₀H₁₉FN₄O₄

InChI: InChI=1S/C20H19FN4O4/c21-14-5-11-17(25(10-1-2-10)7-13(19(11)26)20(27)28)12(6-22)18(14)24-8-15-16(9-24)29-4-3-23-15/h5,7,10,15-16,23H,1-4,8-9H2,(H,27,28)/t15-,16-/m0/s1

InChI key: InChIKey=FYMHQCNFKNMJAV-HOTGVXAUSA-N

SMILES: C(#N)C1=C2N(C=C(C(O)=O)C(=O)C2=CC(F)=C1N3C[C@]4([C@](C3)(OCCN4)[H])[H])C5CC5

Synonyms:

• 3-Quinolinecarboxylic acid, 8-cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b]-1,4-oxazin-6(2H)-yl]-1,4-dihydro-4-oxo-
• 8-Cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b]-1,4-oxazin-6(2H)-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
• Bay-35-3377
• By-377
• Finafloxacin
• Finafloxacin Hydrochloride
• Xtoro
• BAY35-3377,finafloxacin hydrochloride
• (-)-(4aS,7aS)-8-Cyano-1-cyclopropyl-6-fluoro-4-oxo-7-(perhydropyrrolo[3,4-b]-1,4-oxazin-6-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
• 8-cyano-1-cyclopropyl-6-fluoro-7-((4aS,7aS)-hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• 100827
• Finafloxacin >=95% (HPLC)
• 8-Cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

Finafloxacin

CAS: 209342-40-5

Finafloxacin is a fluoroquinolone antibacterial agent, which is a synthetic compound derived from the quinolone family. It functions through the inhibition of bacterial DNA gyrase and topoisomerase IV, crucial enzymes in the replication, transcription, and repair of bacterial DNA. This mechanism leads to the prevention of bacterial cell division and ultimately results in cell death.

Formula: C₂₀H₁₉FN₄O₄

Purity: Min. 95%

Molecular weight: 398.39 g/mol

Ref: 3D-FC138682

Finafloxacin

CAS: 209342-40-5

Finafloxacin is a pH-activated fluoroquinolone, most effective at pH 5.0-6.0, targeting bacterial topoisomerases, used for UTIs and H. pylori infections.

Formula: C₂₀H₁₉FN₄O₄

Color and Shape: Solid

Molecular weight: 398.39

Ref: TM-T11289