CAS 209467-52-7

Ceftobiprole

Description:

Ceftobiprole is a broad-spectrum cephalosporin antibiotic, primarily used for the treatment of various bacterial infections, including those caused by methicillin-resistant Staphylococcus aureus (MRSA). It exhibits a unique mechanism of action by binding to penicillin-binding proteins, which inhibits bacterial cell wall synthesis, leading to cell lysis and death. Ceftobiprole is effective against both Gram-positive and Gram-negative bacteria, making it a valuable option in treating complicated skin and soft tissue infections as well as community-acquired pneumonia. The compound is typically administered intravenously and has a favorable pharmacokinetic profile, allowing for effective dosing regimens. Its stability against certain beta-lactamases enhances its efficacy against resistant strains. Ceftobiprole is generally well-tolerated, though potential side effects may include allergic reactions, gastrointestinal disturbances, and alterations in liver function tests. As with all antibiotics, appropriate susceptibility testing is recommended to ensure its effectiveness against specific pathogens.

Formula: C₂₀H₂₂N₈O₆S₂

InChI: InChI=1/C20H22N8O6S2/c21-20-24-14(26-36-20)11(25-34)15(29)23-12-17(31)28-13(19(32)33)9(7-35-18(12)28)5-8-2-4-27(16(8)30)10-1-3-22-6-10/h5,10,12,18,22,34H,1-4,6-7H2,(H,23,29)(H,32,33)(H2,21,24,26)/b8-5+,25-11-/t10-,12-,18-/m1/s1

InChI key: InChIKey=VOAZJEPQLGBXGO-SDAWRPRTSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\O)/C3=NSC(N)=N3)=O)C2=O)(SCC1/C=C\4/C(=O)N(CC4)[C@@H]5CCNC5)[H]

Synonyms:

• (6R,7R)-7-((2Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)-acetamido)-8-oxo-3-((E)((3'R)-2-oxo-(1,3'-bipyrrolidin)-3-ylidene)-methyl)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid antibiotic
• (6R,7R)-7-[[(2Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino]-8-oxo-3-[(E)-[(3′R)-2-oxo[1,3′-bipyrrolidin]-3-ylidene]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2Z)-(5-amino-1,2,4-thiadiazol-3-yl)(hydroxyimino)acetyl)amino)-8-oxo-3-((E)-((3'R)-2-oxo(1,3'-bipyrrolidin)-3-ylidene)methyl)-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(5-amino-1,2,4-thiadiazol-3-yl)(hydroxyimino)acetyl]amino]-8-oxo-3-[(E)-[(3′R)-2-oxo[1,3′-bipyrrolidin]-3-ylidene]methyl]-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino]-8-oxo-3-[(E)-[(3′R)-2-oxo[1,3′-bipyrrolidin]-3-ylidene]methyl]-, (6R,7R)-
• Bal 9141
• Bal 9141-000
• Ro 63-9141
• Unii-5T97333Yzk
• CS-734
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2Z)-2-(5-aMino-1,2,4-thiadiazol-3-yl)-2-(hydroxyiMino)acetyl]aMino]-8-oxo-3-[(E)-[(3'R)-2-oxo[1,3'-bipyrrolidin]-3-ylidene]Methyl]-,(6R,7R)-

Ceftobiprole

CAS: 209467-52-7

Ceftobiprole

Purity: ≥95%

Molecular weight: 534.57g/mol

Ref: 54-BUP01563

Ceftobiprole

CAS: 209467-52-7

Formula: C₂₀H₂₂N₈O₆S₂

Molecular weight: 534.57

Ref: 4Z-C-349001

Ceftobiprole-15N-d4

CAS: 209467-52-7

Formula: C₂₀H₁₈D₄N₇₁₅NO₆S₂

Molecular weight: 539.58

Ref: 4Z-C-349002

Ceftobiprole

CAS: 209467-52-7

Ceftobiprole (Ro 63-9141) is a β-lactam antibacterial agent that exhibits potent bactericidal activity by binding to PBPs.Cost-effective and quality-assured.

Formula: C₂₀H₂₂N₈O₆S₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 534.57

Ref: TM-TQ0077

Ceftobiprole

CAS: 209467-52-7

Ceftobiprole is a new drug that belongs to the class of beta-lactam antibiotics. It is active against bacteria resistant to penicillin, such as methicillin-resistant Staphylococcus aureus (MRSA), and has shown activity against other bacteria, including multidrug-resistant Enterobacteriaceae. Ceftobiprole has been shown to be effective in treating infections of the skin and soft tissue due to bacterial strains. The mechanism of action for ceftobiprole involves inhibition of cell wall synthesis by binding to penicillin-binding proteins, which prevents cross-linkage of peptidoglycan chains. Ceftobiprole also inhibits protein synthesis by binding to ribosomes and preventing the formation of the initiation complex.

Formula: C₂₀H₂₂N₈O₆S₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 534.57 g/mol

Ref: 3D-FC179087