CAS 2097938-59-3

Spiro[cyclohexane-1,9′(6′H)-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one, 7′,8′-dihydro-2′-[[5-[4-(1-methylethyl)-1-piperazinyl]-2-pyridinyl]amino]-, hydrochloride (1:2)

Description:

Spiro[cyclohexane-1,9′(6′H)-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one, 7′,8′-dihydro-2′-[[5-[4-(1-methylethyl)-1-piperazinyl]-2-pyridinyl]amino]-, hydrochloride (1:2), identified by CAS number 2097938-59-3, is a complex organic compound characterized by its unique spirocyclic structure. This compound features a bicyclic framework that includes a pyrazino-pyrrolo-pyrimidine core, which contributes to its potential biological activity. The presence of a piperazine moiety suggests possible interactions with biological targets, making it of interest in medicinal chemistry. The hydrochloride salt form indicates enhanced solubility and stability, which is often advantageous for pharmaceutical applications. Its molecular structure may exhibit various functional groups that can participate in hydrogen bonding and other interactions, influencing its pharmacokinetic properties. Overall, this compound's intricate architecture and functionalization position it as a candidate for further investigation in drug development, particularly in areas related to neuropharmacology or oncology.

Formula: C₂₆H₃₄N₈O·2ClH

InChI: InChI=1S/C26H34N8O.2ClH/c1-18(2)32-10-12-33(13-11-32)20-6-7-22(27-16-20)30-25-28-15-19-14-21-24(35)29-17-26(8-4-3-5-9-26)34(21)23(19)31-25;;/h6-7,14-16,18H,3-5,8-13,17H2,1-2H3,(H,29,35)(H,27,28,30,31);2*1H

InChI key: InChIKey=IUIVDLVJNPANBY-UHFFFAOYSA-N

SMILES: O=C1C=2N(C3(CN1)CCCCC3)C=4C(C2)=CN=C(NC5=CC=C(C=N5)N6CCN(C(C)C)CC6)N4.Cl

Synonyms:

• G1T38
• Spiro[cyclohexane-1,9′(6′H)-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one, 7′,8′-dihydro-2′-[[5-[4-(1-methylethyl)-1-piperazinyl]-2-pyridinyl]amino]-, hydrochloride (1:2)

Lerociclib dihydrochloride

CAS: 2097938-59-3

Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 2 nM and 1 nM for CDK6/CyclinD3 and CDK4/

Formula: C₂₆H₃₆Cl₂N₈O

Purity: 97.4%

Color and Shape: Solid

Molecular weight: 547.52

Ref: TM-T11345L

Lerociclib dihydrochloride

CAS: 2097938-59-3

Lerociclib dihydrochloride

Purity: ≥95%

Molecular weight: 547.52g/mol

Ref: 54-BUP16277

Lerociclib dihydrochloride

CAS: 2097938-59-3

Lerociclib dihydrochloride is a selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor, which is derived from targeted chemical synthesis. Its mode of action involves binding to CDK4/6 and inhibiting their activity, which in turn blocks the phosphorylation of the retinoblastoma (Rb) protein. This results in the prevention of cell cycle progression from the G1 to the S phase, thereby exerting antiproliferative effects on tumor cells that rely on the CDK4/6 pathway.

Formula: C₂₆H₃₆Cl₂N₈O

Purity: Min. 95%

Molecular weight: 547.5 g/mol

Ref: 3D-XID93859