CAS 209799-67-7

Immucillin H

Description:

Immucillin H is a synthetic compound known for its role as a potent inhibitor of purine nucleoside phosphorylase (PNP), an enzyme involved in purine metabolism. This compound is characterized by its unique structure, which includes a bicyclic framework that contributes to its biological activity. Immucillin H exhibits high specificity for PNP, making it a valuable tool in biochemical research and potential therapeutic applications, particularly in the context of immunosuppression and cancer treatment. The compound is typically administered in a laboratory setting, and its efficacy is often evaluated through various biochemical assays. Additionally, Immucillin H is soluble in organic solvents, which facilitates its use in experimental protocols. Its mechanism of action involves the competitive inhibition of the enzyme, leading to altered purine metabolism, which can have significant implications in cellular processes. Overall, Immucillin H represents an important compound in the study of enzyme inhibition and its potential therapeutic applications.

Formula: C₁₁H₁₄N₄O₄

InChI: InChI=1S/C11H14N4O4/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19)/t5-,7+,9-,10+/m1/s1

InChI key: InChIKey=IWKXDMQDITUYRK-KUBHLMPHSA-N

SMILES: O[C@H]1[C@H](C=2C3=C(NC2)C(=O)N=CN3)N[C@H](CO)[C@H]1O

Synonyms:

• (7-[(2S,3S,4R,5R)-3,4-dihydioxy-5- (hydroxymethyl)-2-pyrrolidinyl]-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one)
• 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-1,5-dihydro-
• 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-3,5-dihydro-
• 7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
• 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
• 7-[3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one hydrochloride
• Fodosine
• Immucillin-H
• Ntr 001
• Forodesine

Fodosine

CAS: 209799-67-7

Formula: C₁₁H₁₄N₄O₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 266.2533

Ref: IN-DA002KEW

7-((2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

CAS: 209799-67-7

7-((2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

Purity: 99%

Molecular weight: 266.26g/mol

Ref: 54-OR1074790

Forodesine

CAS: 209799-67-7

Forodesine inhibits lymphocyte growth and induces apoptosis in leukemic cells; oral purine nucleoside phosphorylase blocker; IC50: 0.48-1.57 nM.

Formula: C₁₁H₁₄N₄O₄

Purity: 98.75% - 99.88%

Color and Shape: Solid

Molecular weight: 266.25

Ref: TM-T15337

Forodesine

CAS: 209799-67-7

Forodesine is a purine nucleoside that inhibits the nucleoside phosphorylase enzyme and prevents the synthesis of purines. It has minimal toxicity and is effective against intracellular targets such as mitochondria, which are important for apoptosis induction. Forodesine also inhibits the mcl-1 protein, which is an inhibitor of t-cell lymphomas. This drug has been shown to be effective in animal models of human lymphoma and leukemia.

Formula: C₁₁H₁₄N₄O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 266.25 g/mol

Ref: 3D-MD11591