CAS 2098545-89-0

4-((2-chlorophenyl)amino)-6-((6-methylpyridin-2-yl)amino)nicotinamide

Description:

4-((2-chlorophenyl)amino)-6-((6-methylpyridin-2-yl)amino)nicotinamide, identified by its CAS number 2098545-89-0, is a synthetic organic compound that belongs to the class of nicotinamide derivatives. This compound features a nicotinamide core, which is a derivative of niacin (vitamin B3), and is substituted with two distinct amino groups: one derived from 2-chlorophenyl and the other from 6-methylpyridin-2-yl. The presence of the chlorophenyl group may impart specific electronic properties and influence the compound's biological activity, while the methylpyridine moiety can enhance lipophilicity and potentially improve membrane permeability. This compound is of interest in medicinal chemistry, particularly for its potential pharmacological applications, which may include roles in cancer therapy or as an enzyme inhibitor. Its solubility, stability, and reactivity would depend on the specific conditions, such as pH and solvent, making it essential to consider these factors in experimental settings.

Formula: C₁₈H₁₆ClN₅O

Synonyms:

• 3-Pyridinecarboxamide, 4-[(2-chlorophenyl)amino]-6-[(6-methyl-2-pyridinyl)amino]-
• CEE321
• 4-((2-chlorophenyl)amino)-6-((6-methylpyridin-2-yl)amino)nicotinamide

CEE321

CAS: 2098545-89-0

CEE321 is an effective pan-JAK inhibitor with an IC50 of 54 nM. It effectively inhibits biomarkers associated with atopic dermatitis.

Formula: C₁₈H₁₆ClN₅O

Color and Shape: Solid

Molecular weight: 353.806

Ref: TM-T204824