CAS 20987-24-0

(3beta,5beta,15beta,17xi)-3-hydroxy-19-oxo-14,15-epoxybufa-20,22-dienolide

Description:

The chemical substance known as (3beta,5beta,15beta,17xi)-3-hydroxy-19-oxo-14,15-epoxybufa-20,22-dienolide, with the CAS number 20987-24-0, is a naturally occurring compound belonging to the class of bufadienolides, which are steroidal compounds derived from toads and certain plants. This compound features a complex steroidal structure characterized by multiple functional groups, including a hydroxyl group and an epoxy group, which contribute to its biological activity. The presence of the 19-oxo group indicates a ketone functionality, while the dienolide structure suggests potential reactivity and interaction with biological targets. Bufadienolides are known for their pharmacological properties, including cardiotonic effects, and may exhibit cytotoxicity against various cancer cell lines. The specific stereochemistry of this compound, indicated by the beta and xi designations, plays a crucial role in determining its biological activity and interaction with receptors. Overall, this compound represents a significant interest in medicinal chemistry and pharmacology due to its potential therapeutic applications.

Formula: C₂₄H₃₀O₅

InChI: InChI=1/C24H30O5/c1-22-8-7-17-18(4-3-15-10-16(26)6-9-23(15,17)13-25)24(22)20(29-24)11-19(22)14-2-5-21(27)28-12-14/h2,5,12-13,15-20,26H,3-4,6-11H2,1H3/t15-,16+,17+,18-,19?,20-,22-,23-,24-/m1/s1

Resibufagin

CAS: 20987-24-0

Resibufagin shows strong cytotoxic activity against HeLa cell line.

Formula: C₂₄H₃₀O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 398.499

Ref: TM-TN2142

Resibufagin

CAS: 20987-24-0

Formula: C₂₄H₃₀O₅

Purity: 95%~99%

Molecular weight: 398.499

Ref: BP-BP3645

Resibufagin

CAS: 20987-24-0

Resibufagin is a cardiotonic steroid, which is derived from the secretions of the Asian toad, Bufo gargarizans. This compound is classified under bufadienolides, a group of naturally occurring steroids known for their distinctive structures and pronounced bioactivity. The primary mode of action of resibufagin involves the inhibition of the Na+/K+-ATPase enzyme, a crucial membrane-bound protein responsible for maintaining the electrochemical gradients of sodium and potassium ions across cell membranes. This inhibition disrupts ion homeostasis, leading to increased intracellular calcium levels, which enhances cardiac contractility.

Formula: C₂₄H₃₀O₅

Purity: Min. 95%

Molecular weight: 398.5 g/mol

Ref: 3D-VAA98724