CAS 209984-57-6

(αS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxybenzeneacetamide

Description:

The chemical substance with the name "(αS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxybenzeneacetamide" and CAS number "209984-57-6" is a complex organic compound characterized by its specific stereochemistry and functional groups. It features a dibenzodiazepine core, which is known for its biological activity, particularly in pharmacology. The presence of difluoro and hydroxy groups suggests potential interactions with biological targets, enhancing its solubility and reactivity. The compound's structure indicates it may exhibit properties such as enzyme inhibition or receptor modulation, making it of interest in medicinal chemistry. Its stereochemical configuration, denoted by the (αS) and (1S) designations, implies that it may have specific interactions in biological systems, which can influence its efficacy and safety profile. Overall, this compound represents a class of molecules that could be explored for therapeutic applications, particularly in areas related to neurological or psychiatric disorders.

Formula: C₂₆H₂₃F₂N₃O₄

InChI: InChI=1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23-/m0/s1

InChI key: InChIKey=ULSSJYNJIZWPSB-CVRXJBIPSA-N

SMILES: N(C([C@@H](NC([C@@H](O)C1=CC(F)=CC(F)=C1)=O)C)=O)[C@H]2C=3C(C=4C(N(C)C2=O)=CC=CC4)=CC=CC3

Synonyms:

• (αS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxybenzeneacetamide
• Ly 411,575
• Ly411575
• Benzeneacetamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxy-, (αS)-

Benzeneacetamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxy-, (αS)-

CAS: 209984-57-6

Formula: C₂₆H₂₃F₂N₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 479.4753

Ref: IN-DA002KI7

LY-411575

CAS: 209984-57-6

LY-411575

Purity: 98%

Molecular weight: 479.48g/mol

Ref: 54-PC108511

LY-411575

CAS: 209984-57-6

LY-411575

Purity: ≥95%

Molecular weight: 479.48g/mol

Ref: 54-BUP10011

LY-411575

CAS: 209984-57-6

Formula: C₂₆H₂₃F₂N₃O₄

Purity: >95.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 479.48

Ref: 3B-L0359

LY-411575

CAS: 209984-57-6

LY-411575, a potent γ-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage.

Formula: C₂₆H₂₃F₂N₃O₄

Purity: 97.03% - 99.38%

Color and Shape: Solid

Molecular weight: 479.48

Ref: TM-T6063

LY 411575

CAS: 209984-57-6

Potent inhibitor of γ-secretase. LY 411575 inhibited production of amyloid β (Aβ) peptides with IC50 of 0.078 nM in vitro as well as decreased levels of Aβ40 and Aβ42 amyloids in brain of a mouse model for Alzheimer’s disease. In vitro studies confirmed that LY 411575 inhibited cleavage of Notch receptor at S3 site with IC50 of 0.39 nM, which blocked Notch activation and downstream signalling, leading to apoptosis in primary and immortalized Kaposi's sarcoma cells.

Formula: C₂₆H₂₃F₂N₃O₄

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 479.48 g/mol

Ref: 3D-FL104120