CAS 2104-68-9

8-chloroguanosine

Description:

8-Chloroguanosine is a modified nucleoside that features a chlorine atom substituted at the 8-position of the guanine base. It is classified as a purine nucleoside, consisting of a ribose sugar linked to the chlorinated guanine. This compound is known for its potential biological activities, including antiviral and anticancer properties, making it of interest in pharmaceutical research. The presence of the chlorine atom can influence its interactions with nucleic acids and enzymes, potentially altering its metabolic pathways and biological effects compared to unmodified guanosine. 8-Chloroguanosine is soluble in water and exhibits stability under physiological conditions, although its reactivity may vary depending on the environment. Its unique structure allows it to participate in various biochemical processes, including RNA synthesis and modification. As a research chemical, it serves as a valuable tool for studying nucleic acid function and the effects of halogenated nucleosides in biological systems.

Formula: C₁₀H₁₂ClN₅O₅

InChI: InChI=1/C10H12ClN5O5/c11-9-13-3-6(14-10(12)15-7(3)20)16(9)8-5(19)4(18)2(1-17)21-8/h2,4-5,8,17-19H,1H2,(H3,12,14,15,20)/t2-,4-,5-,8-/m1/s1

SMILES: C([C@@H]1[C@H]([C@H]([C@H](n2c3c(c(nc(=N)[nH]3)O)nc2Cl)O1)O)O)O

Synonyms:

• Guanosine, 8-Chloro-

Guanosine, 8-chloro-

CAS: 2104-68-9

Formula: C₁₀H₁₂ClN₅O₅

Purity: 97%

Molecular weight: 317.6858

Ref: IN-DA002KRE

8-Chloroguanosine

CAS: 2104-68-9

Ref: 7W-GN8904

2-Amino-8-chloro-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one

CAS: 2104-68-9

2-Amino-8-chloro-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one

Purity: 97%

Molecular weight: 317.69g/mol

Ref: 54-OR1074256

8-Chloroguanosine

CAS: 2104-68-9

8-Chloroguanosine is a Nucleoside Derivative - Halo-nucleoside, 8-Modified purine nucleoside.

Formula: C₁₀H₁₂ClN₅O₅

Color and Shape: Solid

Molecular weight: 317.69

Ref: TM-TNU0315

8-Chloroguanosine

CAS: 2104-68-9

8-Chloroguanosine is a purine nucleoside that is activated by the addition of adenosine triphosphate (ATP). It reacts with DNA to form a covalent glycosidic bond. 8-Chloroguanosine has been found in urine samples and cell nuclei, as well as in activated and reactive sites in DNA. 8-Chloroguanosine is genotoxic and can cause oxidative damage to DNA. It also has potential as a biomarker for atherosclerosis, because it can be used to detect the group P2 phosphorylation status of proteins in lesions on arteries.

Formula: C₁₀H₁₂ClN₅O₅

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 317.69 g/mol

Ref: 3D-NC06679