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CAS 210421-74-2

:

Thelin

Description:
Thelin, with the CAS number 210421-74-2, is a chemical compound known for its role as a selective pulmonary vasodilator. It is primarily used in the treatment of pulmonary arterial hypertension (PAH), a condition characterized by elevated blood pressure in the pulmonary arteries. Thelin works by relaxing the blood vessels in the lungs, thereby improving blood flow and reducing the workload on the heart. This compound is often administered in oral form and is known to have a favorable pharmacokinetic profile, allowing for once-daily dosing. Its mechanism of action involves the inhibition of the enzyme phosphodiesterase type 5 (PDE5), which leads to increased levels of cyclic guanosine monophosphate (cGMP) and subsequent vasodilation. Thelin is generally well-tolerated, but like all medications, it may have side effects, including headaches, flushing, and gastrointestinal disturbances. Regular monitoring and consultation with a healthcare provider are essential for patients using this medication to manage PAH effectively.
Formula:C18H14ClN2NaO6S2
InChI:InChI=1/C18H14ClN2O6S2.Na/c1-9-5-13-14(26-8-25-13)7-11(9)6-12(22)17-15(3-4-28-17)29(23,24)21-18-16(19)10(2)20-27-18;/h3-5,7H,6,8H2,1-2H3;/q-1;+1/rC18H14ClN2NaO6S2/c1-9-5-13-14(27-8-26-13)7-11(9)6-12(23)17-15(3-4-29-17)30(24,25)21(22)18-16(19)10(2)20-28-18/h3-5,7H,6,8H2,1-2H3
InChI key:InChIKey=HRFIVLUXADNCHX-UHFFFAOYSA-N
SMILES:C(CC=1C=C2C(=CC1C)OCO2)(=O)C3=C(S(NC4=C(Cl)C(C)=NO4)(=O)=O)C=CS3.[Na]
Synonyms:
  • 3-Thiophenesulfonamide, N-(4-chloro-3-methyl-5-isoxazolyl)-2-[(6-methyl-1,3-benzodioxol-5-yl)acetyl]-, sodium salt
  • 3-Thiophenesulfonamide, N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]-, sodium salt (1:1)
  • 4-Chloro-3-methyl-5-[2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]-3-thienylsulfonamido]isoxazole sodium salt
  • Sitaxentan sodium
  • Sodium (4-chloro-3-methyl-1,2-oxazol-5-yl)-[2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]thiophen-3-yl]sulfonylazanide
  • TBC 11251 sodium salt
  • TBC 11251z
  • Thelin
  • Sitaxsentan sodiuM(TBC-11249)
  • Sitaxentan sodium (Sitaxsentan
  • See more synonyms
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