CAS 210421-74-2

Thelin

Description:

Thelin, with the CAS number 210421-74-2, is a chemical compound known for its role as a selective pulmonary vasodilator. It is primarily used in the treatment of pulmonary arterial hypertension (PAH), a condition characterized by elevated blood pressure in the pulmonary arteries. Thelin works by relaxing the blood vessels in the lungs, thereby improving blood flow and reducing the workload on the heart. This compound is often administered in oral form and is known to have a favorable pharmacokinetic profile, allowing for once-daily dosing. Its mechanism of action involves the inhibition of the enzyme phosphodiesterase type 5 (PDE5), which leads to increased levels of cyclic guanosine monophosphate (cGMP) and subsequent vasodilation. Thelin is generally well-tolerated, but like all medications, it may have side effects, including headaches, flushing, and gastrointestinal disturbances. Regular monitoring and consultation with a healthcare provider are essential for patients using this medication to manage PAH effectively.

Formula: C₁₈H₁₄ClN₂NaO₆S₂

InChI: InChI=1/C18H14ClN2O6S2.Na/c1-9-5-13-14(26-8-25-13)7-11(9)6-12(22)17-15(3-4-28-17)29(23,24)21-18-16(19)10(2)20-27-18;/h3-5,7H,6,8H2,1-2H3;/q-1;+1/rC18H14ClN2NaO6S2/c1-9-5-13-14(27-8-26-13)7-11(9)6-12(23)17-15(3-4-29-17)30(24,25)21(22)18-16(19)10(2)20-28-18/h3-5,7H,6,8H2,1-2H3

InChI key: InChIKey=HRFIVLUXADNCHX-UHFFFAOYSA-N

SMILES: C(CC=1C=C2C(=CC1C)OCO2)(=O)C3=C(S(NC4=C(Cl)C(C)=NO4)(=O)=O)C=CS3.[Na]

Synonyms:

• 3-Thiophenesulfonamide, N-(4-chloro-3-methyl-5-isoxazolyl)-2-[(6-methyl-1,3-benzodioxol-5-yl)acetyl]-, sodium salt
• 3-Thiophenesulfonamide, N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]-, sodium salt (1:1)
• 4-Chloro-3-methyl-5-[2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]-3-thienylsulfonamido]isoxazole sodium salt
• Sitaxentan sodium
• Sodium (4-chloro-3-methyl-1,2-oxazol-5-yl)-[2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]thiophen-3-yl]sulfonylazanide
• TBC 11251 sodium salt
• TBC 11251z
• Thelin
• Sitaxsentan sodiuM(TBC-11249)
• Sitaxentan sodium (Sitaxsentan
• Sitaxsentan sodiuM (TBC-11251)
• Sitaxsentan sodium salt
• N-(4-Chloro-3-Methyl-5-isoxazolyl)-2-[2-(6-Methyl-1,3-benzodioxol-5-yl)acetyl]-3-thiophenesulfonaMide
• TBC11251 sodiuM salt
• TBC-11251 sodium
• CS-777
• TBC-11250
• Sitaxentan sodium USP/EP/BP
• Sodium (4-chloro-3-methylisoxazol-5-yl)((2-(2-(6-methylbenzo[d][1,3]dioxol-5-yl)acetyl)thiophen-3-yl)sulfonyl)amide
• SITAXSENTAN SODIUM
• TBC-11249
• Sitaxentan sodium salt
• N-(4-Chloro-3-methyl-5-isoxazolyl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]-3-thiophenesulfonamide sodium salt
• CS-338

3-Thiophenesulfonamide, N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]-, sodium salt (1:1)

CAS: 210421-74-2

Formula: C₁₈H₁₄ClN₂NaO₆S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 476.8863

Ref: IN-DA002KRR

Sitaxsentan sodium

CAS: 210421-74-2

Sitaxsentan sodium

Purity: ≥95%

Molecular weight: 476.89g/mol

Ref: 54-BUP15545

Sitaxsentan sodium

CAS: 210421-74-2

Formula: C₁₈H₁₄ClN₂NaO₆S₂

Molecular weight: 476.89

Ref: 7W-GP2794

Sitaxsentan sodium

CAS: 210421-74-2

Sitaxsentan sodium (TBC11251 sodium salt) is a highly selective antagonist of endothelin A receptors.

Formula: C₁₈H₁₄ClN₂O₆S₂·Na

Purity: 98.39% - 99.01%

Color and Shape: Solid

Molecular weight: 476.89

Ref: TM-T6672

Sitaxsentan sodium

CAS: 210421-74-2

Endothelin A receptor antagonist

Formula: C₁₈H₁₄ClN₂NaO₆S₂

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 476.89 g/mol

Ref: 3D-FS27842

Sitaxsentan Sodium

Controlled Product

CAS: 210421-74-2

Formula: C₁₈H₁₄ClN₂O₆S₂·Na

Color and Shape: Neat

Molecular weight: 476.886

Ref: TR-S493500