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CAS 210759-10-7

:

3-[(R)-2-(N,N-dimethylamino)ethylthio-Sar]-4-(3-hydroxymethylleucine)cyclosporin

Description:
3-[(R)-2-(N,N-dimethylamino)ethylthio-Sar]-4-(3-hydroxymethylleucine)cyclosporin, identified by its CAS number 210759-10-7, is a synthetic derivative of cyclosporin, a cyclic peptide known for its immunosuppressive properties. This compound features a complex structure that includes a thioether linkage and a hydroxymethyl leucine moiety, which contribute to its biological activity. The presence of the N,N-dimethylamino group enhances its solubility and may influence its pharmacokinetic properties. Like other cyclosporins, this compound is likely to exhibit high affinity for cyclophilin, a key protein involved in immunoregulation. Its unique modifications may also affect its potency, selectivity, and side effect profile compared to traditional cyclosporin. The compound is primarily studied for its potential therapeutic applications in organ transplantation and autoimmune diseases, where modulation of the immune response is crucial. As with many peptide-based drugs, stability, bioavailability, and route of administration are important factors influencing its clinical use.
Formula:C66H120N12O13S
Synonyms:
  • SCY-635 210759-10-7
  • (3S,6S,9S,12R,15S,18S,21S,24S,27R,30S,33S)-27-((2-(Dimethylamino)ethyl)thio)-30-ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-24-(2-hydroxy-2-methylpropyl)-6,9,18-triisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
  • (3S,6S,9S,12R,15S,18S,21S,24S,27R,30S,33S)-27-[2-(dimethylamino)ethylsulfanyl]-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-24-(2-hydroxy-2-methylpropyl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18-tris(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
  • 3-[(R)-2-(N,N-dimethylamino)ethylthio-Sar]-4-(3-hydroxymethylleucine)cyclosporin
  • SCY-635
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