CAS 211100-13-9

Sabarubicin

Description:

Sabarubicin, with the CAS number 211100-13-9, is an anthracycline antibiotic that is primarily used in the field of oncology for its antitumor properties. It is derived from the natural product doxorubicin and is known for its ability to intercalate DNA, thereby inhibiting the synthesis of nucleic acids and disrupting the replication of cancer cells. Sabarubicin exhibits a broad spectrum of activity against various types of tumors, including solid tumors and hematological malignancies. Its mechanism of action involves the generation of free radicals, which contribute to cellular damage and apoptosis in cancer cells. Additionally, Sabarubicin has been studied for its potential to overcome drug resistance commonly seen with other chemotherapeutic agents. While it shows promise in clinical settings, its use is often accompanied by side effects typical of anthracyclines, such as cardiotoxicity and myelosuppression. Ongoing research aims to optimize its therapeutic efficacy while minimizing adverse effects, making it a subject of interest in cancer treatment protocols.

Formula: C₃₂H₃₇NO₁₃

InChI: InChI=1S/C32H37NO13/c1-12-26(37)17(33)7-21(43-12)46-31-13(2)44-22(8-18(31)35)45-19-10-32(42,20(36)11-34)9-16-23(19)30(41)25-24(29(16)40)27(38)14-5-3-4-6-15(14)28(25)39/h3-6,12-13,17-19,21-22,26,31,34-35,37,40-42H,7-11,33H2,1-2H3/t12-,13-,17-,18-,19-,21-,22-,26+,31+,32-/m0/s1

InChI key: InChIKey=VQHRZZISQVWPLK-UIRGBLDSSA-N

SMILES: O([C@@H]1C2=C(C(O)=C3C(=C2O)C(=O)C=4C(C3=O)=CC=CC4)C[C@](C(CO)=O)(O)C1)[C@H]5C[C@H](O)[C@H](O[C@H]6C[C@H](N)[C@H](O)[C@H](C)O6)[C@H](C)O5

Synonyms:

• (7S,9S)-7-[[4-O-(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)-2,6-dideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-5,12-naphthacenedione
• 5,12-Naphthacenedione, 7-[[4-O-(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)-2,6-dideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-, (7S,9S)-
• 5,12-Naphthacenedione, 7-[[4-O-(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)-2,6-dideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-(hydroxyacetyl)-, (7S,9S)-
• Sabarubicin

Sabarubicin

CAS: 211100-13-9

Sabarubicin: a doxorubicin analogue with potent antitumor effects; superior in DNA fragmentation and topoisomerase II poisoning.

Formula: C₃₂H₃₇NO₁₃

Color and Shape: Solid

Molecular weight: 643.64

Ref: TM-T69896