CAS 211110-63-3

Sobetirome

Description:

Sobetirome, also known by its chemical name, is a synthetic thyroid hormone analog primarily developed for the treatment of conditions related to thyroid hormone deficiency and metabolic disorders. It acts as a selective thyroid hormone receptor modulator, specifically targeting the thyroid hormone receptor beta (TRβ), which is involved in regulating metabolism and energy expenditure. Sobetirome is characterized by its ability to enhance lipid metabolism and improve insulin sensitivity without the typical side effects associated with traditional thyroid hormone therapies. Its pharmacological profile suggests potential benefits in managing obesity and dyslipidemia. The compound is typically administered in a controlled dosage to minimize adverse effects and optimize therapeutic outcomes. As with any medication, its use should be guided by clinical evaluation and monitoring to ensure safety and efficacy. Research continues to explore its full potential and applications in various metabolic disorders.

Formula: C₂₀H₂₄O₄

InChI: InChI=1/C20H24O4/c1-12(2)17-9-15(5-6-19(17)21)10-18-13(3)7-16(8-14(18)4)24-11-20(22)23/h5-9,12,21H,10-11H2,1-4H3,(H,22,23)

InChI key: InChIKey=QNAZTOHXCZPOSA-UHFFFAOYSA-N

SMILES: C(C1=C(C)C=C(OCC(O)=O)C=C1C)C2=CC(C(C)C)=C(O)C=C2

Synonyms:

• 2-(4-(4-Hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid
• 2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid
• 3,5-Dimethyl-4-(4′-hydroxy-3′-isopropylbenzyl)phenoxyacetic acid
• Acetic Acid, 2-[4-[[4-Hydroxy-3-(1-Methylethyl)Phenyl]Methyl]-3,5-Dimethylphenoxy]-
• Acetic acid, [4-[[4-hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]-
• GC 1 (pharmaceutical)
• Qrx 431
• Sobetirome
• T3 analog GC-1
• Thyroid hormone receptor agonist GC-1
• Thyroid hormone β-receptor agonist GC-1
• [3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]acetic acid
• {4-[4-Hydroxy-3-(Propan-2-Yl)Benzyl]-3,5-Dimethylphenoxy}Acetic Acid
• GC 1
• Anti-SLC25A22, (N-terminal) antibody produced in rabbit
• Sobetirome >=98% (HPLC)
• Anti-NET44
• Anti-SLC25A22 antibody produced in rabbit
• Anti-KIAA4294
• NET44
• GC-1; QRX-431
• Anti-GC1
• Anti-Olfactomedin 4
• Anti-solute carrier family 25 (mitochondrial carrier: glutamate), member 22
• EIEE3
• [4-(4-Hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phenoxy]-acetic acid
• Anti-OlfD
• GC-1 (Sobetirome)
• Anti-FLJ13044
• Anti-GW112

Acetic acid, 2-[4-[[4-hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]-

CAS: 211110-63-3

Formula: C₂₀H₂₄O₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 328.4022

Ref: IN-DA002L62

Sobetirome

CAS: 211110-63-3

Sobetirome

Purity: ≥98%

Molecular weight: 328.4g/mol

Ref: 54-BUP09022

Sobetirome

CAS: 211110-63-3

Sobetirome (IACS-010759) is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).

Formula: C₂₀H₂₄O₄

Purity: 98.08% - 98.25%

Color and Shape: Solid

Molecular weight: 328.4

Ref: TM-T5313

GC 1

Controlled Product

CAS: 211110-63-3

Formula: C₂₀H₂₄O₄

Color and Shape: Neat

Molecular weight: 328.4

Ref: TR-G932045

Sobetirome

CAS: 211110-63-3

Purity: 99%

Molecular weight: 328.408

Ref: 10-F979906

Sobetirome

CAS: 211110-63-3

Sobetirome is a selective small-molecule inhibitor of α subunit of the transcription-polymerase chain. Sobetirome binds to the α subunit and inhibits the polymerase chain reaction (PCR) by blocking DNA synthesis. Sobetirome has been shown to inhibit the growth of tumor cells in culture and in mice, as well as reducing angiogenesis, which may be due to its ability to induce apoptosis. Sobetirome has also shown anti-inflammatory properties, which may be due to its inhibition of epidermal growth factor receptor (EGFR).

Formula: C₂₀H₂₄O₄

Purity: Min. 95%

Molecular weight: 328.4 g/mol

Ref: 3D-FS141791