DSPE-PEG4-DBCO, or 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(polyethylene glycol)-4-azidobenzylamine, is a phospholipid derivative commonly used in bioconjugation and drug delivery applications. It features a hydrophobic tail derived from distearoyl phosphatidylethanolamine (DSPE), which facilitates membrane incorporation, and a hydrophilic polyethylene glycol (PEG) segment that enhances solubility and biocompatibility. The DBCO (dibenzocyclooctyne) moiety allows for efficient and selective click chemistry reactions, particularly with azides, making it valuable for labeling and targeting in various biological systems. This compound is typically utilized in the formulation of liposomes and nanoparticles, improving their stability and circulation time in biological environments. Its unique combination of hydrophobic and hydrophilic properties, along with the reactive DBCO group, makes DSPE-PEG4-DBCO a versatile tool in the fields of nanomedicine and molecular biology, facilitating the development of targeted therapies and diagnostic agents.

DSPE-PEG4-DBCO is a PEG linker containing DSPE and DBCO moieties. The DSPE-PEGs have been FDA approved for medical applications. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG linker increases the water solubility of the overall compound allowing for the delivery of the drug. The DBCO group can be used for copper-free Click Chemistry reactions.

DSPE-PEG4-DBCO

2112738-14-2: DSPE-PEG4-DBCO, or 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(polyethylene glycol)-4-azidobenzylamine, is a phospholipid derivative commonly used in bioconjugation and drug delivery applications. It features a hydrophobic tail derived from distearoyl phosphatidylethanolamine (DSPE), which facilitates membrane incorporation, and a hydrophilic polyethylene glycol (PEG) segment that enhances solubility and biocompatibility. The DBCO (dibenzocyclooctyne) moiety allows for efficient and selective click chemistry reactions, particularly with azides, making it valuable for labeling and targeting in various biological systems. This compound is typically utilized in the formulation of liposomes and nanoparticles, improving their stability and circulation time in biological environments. Its unique combination of hydrophobic and hydrophilic properties, along with the reactive DBCO group, makes DSPE-PEG4-DBCO a versatile tool in the fields of nanomedicine and molecular biology, facilitating the development of targeted therapies and diagnostic agents.

DSPE-PEG4-DBCO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.

CAS 2112738-14-2

DSPE-PEG4-DBCO

DSPE-PEG4-DBCO

Ref: 54-BUP01648

DSPE-PEG4-DBCO

Ref: TM-T17859