![[2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-(isopropoxycarbonyloxymethoxy)phosphinic acid](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fcas-image%2Fthumb-webp%2F363358-mono-poc-tenofovir.webp&w=3840&q=75)
CAS 211364-69-1
:[2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-(isopropoxycarbonyloxymethoxy)phosphinic acid
Description:
The chemical substance known as [2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-(isopropoxycarbonyloxymethoxy)phosphinic acid, with the CAS number 211364-69-1, is a phosphonic acid derivative that exhibits characteristics typical of nucleoside analogs. This compound features a purine base structure, which is significant for its potential biological activity, particularly in antiviral and anticancer applications. The presence of the phosphinic acid moiety suggests that it may interact with biological systems by mimicking natural nucleotides, potentially inhibiting enzymes involved in nucleic acid synthesis. The ethoxy and isopropoxy groups contribute to its solubility and stability, which are crucial for its efficacy in therapeutic contexts. Additionally, the amino group on the purine ring may enhance its interaction with biological targets. Overall, this compound's unique structural features position it as a candidate for further research in medicinal chemistry, particularly in the development of antiviral agents or other therapeutic applications.
Formula:C14H22N5O7P
InChI:InChI=1/C14H22N5O7P/c1-9(2)26-14(20)23-7-25-27(21,22)8-24-10(3)4-19-6-18-11-12(15)16-5-17-13(11)19/h5-6,9-10H,4,7-8H2,1-3H3,(H,21,22)(H2,15,16,17)
SMILES:CC(C)OC(=O)OCOP(=O)(COC(C)Cn1cnc2c(N)ncnc12)O
Synonyms:- Mono-POC Tenofovir
- ((((R)-1-(6-aMino-9H-purin-9-yl)propan-2-yloxy)Methyl)(hydroxy)phosphoryloxy)Methyl isopropyl carbonate
- Mono-POC PMPA
- Tenofovirdisoproxil Impurity I
- 2,4,7-Trioxa-5-phosphanonanoic acid, 9-(6-amino-9H-purin-9-yl)-5-hydroxy-8-methyl-, 1-methylethyl ester, 5-oxide, (8R)-
- Tenofovir Disoproxil Related CoMpound E
- [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphinic acid
- [2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-(isopropoxycar...
- (Mixture of DiastereoMers)
- Tenofovir monoisoproxil
- (R)-1-((9-((R)-2-hydroxypropyl)-9H-purin-6-yl)amino)propan-2-ol
- Tenofovir disoproxil-1
- Mono-POC Tenofovir Q: What is the CAS Number of
- Mono ester Tenofovir
- Tenofovir impurity I
- Tenofovir Disoproxil Impurity A(IP)
- (8R)-9-(6-Amino-9H-purin-9-yl)-5-hydroxy-8-methyl-2,4,7-trioxa-5-phosphanonanoic acid 1-methylethyl ester 5-oxide
- tenofovirMonoester
- Tenofovir disoproxil Impurity T
- Mono-POC Tenofovir Q: What are the applications of
- Tenofovir impurity 1/Mono POC Tenofovir(Mixture of Diastereomers)/((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(hydroxy)phosphoryl)oxy)methyl isopropyl carbonate
- Mono poc-Tenofovir impurity
- Tenofovir Disoproxil Fumarate IP Impurity A
- Mono-POC Tenofovir (Mixture of Diastere)
- Mono-POC TenofovirQ: What is
- isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(4-chlorophenoxy)phosphoryl)-L-alaninate fumarate
- Tenofovir disoproxil Impurity C
- ({[1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)({[(propan-2-yloxy)carbonyl]oxy}methoxy)phosphini
- Tenofovir mono poc
- Tenofovir Disoproxil Fumarate impurity E
- Tenofovir Impurity C
- Tenofovir Disoproxil Related
- Tenofovir Isoproxil Monoester
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Found 6 products.
Tenofovir Soproxil (((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(hydroxy)phosphoryl)oxy)methyl isopropyl carbonate)
CAS:<p>Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi</p>Formula:C14H22N5O7PColor and Shape:White Off-White SolidMolecular weight:403.125692,4,7-Trioxa-5-phosphanonanoic acid, 9-(6-amino-9H-purin-9-yl)-5-hydroxy-8-methyl-, 1-methylethyl ester, 5-oxide, (8R)-
CAS:Formula:C14H22N5O7PPurity:98%Color and Shape:SolidMolecular weight:403.3275Tenofovir Impurity 132
CAS:Formula:C14H22N5O7PColor and Shape:White To Off-White SolidMolecular weight:403.33Mono-POC Tenofovir
CAS:<p>Stability Hygroscopic<br>Applications An impurity of Tenofovir Disoproxil (T018505(P)), which is an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. It is used as an anti-HIV agent and an antiviral.<br>References Gan, L., et al.: Drug Metab. Dispos., 24, 344 (1996), Annaert, P., et al.: Pharm. Res., 14, 492 (1997), Naesens, L., et al.: Antimicrob. Agents Chemother., 42, 1568 (1998), Shaw, J. P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)<br></p>Formula:C14H22N5O7PColor and Shape:White To Light BeigeMolecular weight:403.33Tenofovir isoproxil monoester
CAS:<p>Tenofovir isoproxil monoester is a prodrug of Tenofovir, which is an antiviral drug. Tenofovir prevents the growth of HIV by interfering with the synthesis of viral DNA. The process development stage involves converting Tenofovir to its disoproxil monoester form, which has been shown to have greater antiviral activity than Tenofovir alone. This conversion process involves condensing one molecule of fumarate with two molecules of tenofovir, forming tenofovir disoproxil fumarate (TFD). TFD can be converted back to Tenofovir using hydrolysis and hydrogenation. Impurities in TFD include isopropyl tenofovir and unidentified impurities that are not present in the parent drug, tenofovir. Tenofovir Disoproxil Fumarate was also shown to be more potent than TFD and is undergoing clinical trials for</p>Formula:C14H22N5O7PPurity:Min. 97 Area-%Color and Shape:White/Off-White SolidMolecular weight:403.33 g/mol
