CAS 21149-26-8

8-Hydroxyadenine

Description:

8-Hydroxyadenine is a purine derivative and a modified nucleobase that plays a significant role in various biochemical processes, particularly in DNA and RNA metabolism. It is characterized by the presence of a hydroxyl group at the 8-position of the adenine ring structure, which can lead to its incorporation into nucleic acids, potentially causing mutations. This compound is known for its role as an oxidative stress marker, as it can form as a result of oxidative damage to DNA. In terms of solubility, 8-hydroxyadenine is generally soluble in water and polar organic solvents, making it accessible for various biochemical assays. Its molecular formula is C5H6N4O2, and it has a relatively low molecular weight. The compound is of interest in research related to cancer, aging, and other diseases linked to oxidative stress, as well as in studies investigating the mechanisms of DNA repair and mutagenesis. Overall, 8-hydroxyadenine serves as an important biomarker and a subject of study in molecular biology and genetics.

Formula: C₅H₅N₅O

InChI: InChI=1S/C5H5N5O/c6-3-2-4(8-1-7-3)10-5(11)9-2/h1H,(H4,6,7,8,9,10,11)

InChI key: InChIKey=RGKBRPAAQSHTED-UHFFFAOYSA-N

SMILES: NC1=C2C(NC(=O)N2)=NC=N1

Synonyms:

• 1H-Purin-6-amine, 8-hydroxy-
• 1H-purin-8-ol, 6-amino-
• 6-Amino-1,7-dihydro-8H-purin-8-on
• 6-Amino-1,7-dihydro-8H-purin-8-one
• 6-Amino-8-hydroxypurine
• 6-Amino-9H-purin-8-ol
• 6-amino-1H-purin-8-ol
• 7,8-Dihydro-8-oxoadenine
• 8-Hydroxyadenine
• 8-Oxo-7,8-dihydroadenine
• 8-Oxoadenine
• 8-hydroxy-1H-Purin-6-amine
• 8H-Purin-8-one, 6-amino-1,7-dihydro-
• 8H-purin-8-one, 6-amino-7,9-dihydro-
• 9H-purin-8-ol, 6-amino-
• NSC 24123
• Oksaden
• Oxaden
• Oxyadenine
• Purin-8(9H)-one, 6-amino-
• Purin-8-ol, 6-amino-

6-Amino-7H-purin-8-ol

CAS: 21149-26-8

Formula: C₅H₅N₅O

Purity: 95%

Color and Shape: Solid

Molecular weight: 151.1261

Ref: IN-DA006Z3K

8-Hydroxy Adenine

Controlled Product

CAS: 21149-26-8

Applications Adenine metabolite, which can be used as a plant growth regulator.
References Borrmann, T., et al.: J. Med. Chem., 52, 5974 (2009), Gokce, G., et al.: Biochem., 48, 4980 (2009), Castillo-Garit, J., et al.: Eur. J. Pharm. Sci., 39, 30 (2010),

Formula: C₅H₅N₅O

Color and Shape: Neat

Molecular weight: 151.13

Ref: TR-H750060

8-Hydroxyadenine

CAS: 21149-26-8

8-Hydroxyadenine is a reactive molecule that is used in the treatment of HIV infection. It is an inhibitor of reverse transcriptase and has been used to protect DNA against radiation damage. 8-Hydroxyadenine has been shown to induce a number of genotoxic effects, including neuronal death. 8-Hydroxyadenine can also be used as a DNA probe for the detection of HIV, with the advantage over other probes of having a high specificity for its target sequence.

Formula: C₅H₅N₅O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 151.13 g/mol

Ref: 3D-FH09768

8-Hydroxy Adenine

CAS: 21149-26-8

Formula: C₅H₅N₅O

Molecular weight: 151.13

Ref: ST-EA-CP-A88108