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CAS 211513-37-0

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Dalcetrapib

Description:
Dalcetrapib is a synthetic small molecule that functions primarily as a cholesteryl ester transfer protein (CETP) inhibitor. It was developed with the aim of increasing high-density lipoprotein (HDL) cholesterol levels and improving cardiovascular outcomes. Dalcetrapib is characterized by its unique chemical structure, which includes a phenyl group and a pyridine moiety, contributing to its biological activity. The compound has been studied for its potential to modulate lipid profiles and reduce the risk of atherosclerosis. In clinical trials, Dalcetrapib demonstrated a favorable safety profile, but its efficacy in reducing cardiovascular events has been a subject of debate, leading to mixed results in various studies. The compound is soluble in organic solvents and exhibits specific pharmacokinetic properties, including metabolism primarily through hepatic pathways. Overall, Dalcetrapib represents a significant area of research in lipid management and cardiovascular health, although its clinical utility remains to be fully established.
Formula:C23H35NO2S
InChI:InChI=1S/C23H35NO2S/c1-5-18(6-2)16-23(14-10-7-11-15-23)22(26)24-19-12-8-9-13-20(19)27-21(25)17(3)4/h8-9,12-13,17-18H,5-7,10-11,14-16H2,1-4H3,(H,24,26)
InChI key:InChIKey=YZQLWPMZQVHJED-UHFFFAOYSA-N
SMILES:C(NC1=C(SC(C(C)C)=O)C=CC=C1)(=O)C2(CC(CC)CC)CCCCC2
Synonyms:
  • Dalcetrapib
  • Jtt-705
  • Propanethioic acid, 2-methyl-, S-[2-[[[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino]phenyl] ester
  • JTT-705 (Dalcetrapib)
  • JTT-705 USP/EP/BP
  • RO4607381
  • Dalcetrapib(JTT-705),JTT705
  • Dalcetrapib (JTT-705, RO4607381)
  • 2-Methylpropanethioic acid S-[2-[1-(2-ethylbutyl)cyclohexylcarboxamido]phenyl] ester Dalcetrapib (JTT-705, RO4607381)
  • Thioisobutyric acid S-(2-{[1-(2-ethyl-butyl)-cyclohexanecarbonyl]-aMino}-phenyl) ester
  • See more synonyms
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