CAS 2119-75-7

Fluperolone acetate

Description:

Fluperolone acetate is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. It is primarily used in dermatological formulations to treat various skin conditions, including eczema and dermatitis. The compound exhibits a high affinity for glucocorticoid receptors, which contributes to its effectiveness in reducing inflammation and modulating immune responses. Fluperolone acetate is characterized by its ability to penetrate the skin barrier, allowing for localized therapeutic effects with minimal systemic absorption. Its chemical structure includes a fluorinated steroid backbone, which enhances its potency and stability compared to non-fluorinated corticosteroids. The substance is typically formulated in topical preparations, such as creams or ointments, and is administered externally. Safety and efficacy profiles indicate that, while generally well-tolerated, prolonged use may lead to potential side effects, including skin atrophy or systemic effects if absorbed in significant amounts. As with any corticosteroid, it is essential to use Fluperolone acetate under medical supervision to mitigate risks and ensure appropriate therapeutic outcomes.

Formula: C₂₄H₃₁FO₆

InChI: InChI=1/C24H31FO6/c1-13(31-14(2)26)20(29)23(30)10-8-17-18-6-5-15-11-16(27)7-9-21(15,3)24(18,25)19(28)12-22(17,23)4/h7,9,11,13,17-19,28,30H,5-6,8,10,12H2,1-4H3/t13-,17-,18-,19-,21-,22-,23-,24-/m0/s1

InChI key: InChIKey=HHPZZKDXAFJLOH-QZIXMDIESA-N

SMILES: F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C([C@@H](OC(C)=O)C)=O)(O)CC3)[H])(CCC=4[C@]2(C)C=CC(=O)C4)[H]

Synonyms:

• (11β,17α)-17-[(2S)-2-(Acetyloxy)-1-oxopropyl]-9-fluoro-11,17-dihydroxyandrosta-1,4-dien-3-one
• (2S)-1-[(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl]-1-oxopropan-2-yl acetate (non-preferred name)
• 17(S)-[α-(Acetyloxy)-1-oxopropyl]-9-fluoro-11β,17α-dihydroxyandrosta-1,4-dien-3-one
• 17β-[2-Acetoxypropionyl]-9α-fluoro-11β,17-dihydroxyandrosta-1,4-dien-3-one
• 21-Methyl-9α-fluoroprednisolone acetate
• 9-Fluoro-11beta,17alpha-dihydroxy-17-(S)-lactoylandrosta-1,4-dien-3-one 17beta-acetate
• 9-Fluoro-11beta,17alpha-hydroxy-17-lactoylandrosta-1,4-diene 17beta-acetate
• 9α-Fluoro-11β,17α,21-trihydroxy-21-methylpregna-1,4-diene-3,20-dione 21-acetate
• Alacortril
• Androsta-1,4-dien-3-one, 17-(2-(acetyloxy)-1-oxopropyl)-9-fluoro-11,17-dihydroxy-, (11beta,17alpha,17(S))-
• Androsta-1,4-dien-3-one, 17-[(2S)-2-(acetyloxy)-1-oxopropyl]-9-fluoro-11,17-dihydroxy-, (11β,17α)-
• Androsta-1,4-dien-3-one, 17-[2-(acetyloxy)-1-oxopropyl]-9-fluoro-11,17-dihydroxy-, [11β,17α,17(S)]-
• Androsta-1,4-dien-3-one, 9-fluoro-11β,17α-dihydroxy-17-(S)-lactoyl-, 17β-acetate
• Falban-Crema
• Flu-Korti
• Fluperolone 21-acetate
• Fluperolone acetate
• Fluperolone acetate [USAN]
• Methral
• P 1742
• 9-Fluoro-11β,17α-dihydroxy-17-(S)-lactoylandrosta-1,4-dien-3-one 17β-Acetate
• Fluperolone

Fluperolone Acetate

Controlled Product

CAS: 2119-75-7

Formula: C₂₄H₃₁FO₆

Color and Shape: Neat

Molecular weight: 434.498

Ref: TR-F598150

Fluperolone acetate

CAS: 2119-75-7

Fluperolone acetate is a Glucocorticoid/Adrenal Cortex Hormone.

Formula: C₂₄H₃₁FO₆

Color and Shape: Solid

Molecular weight: 434.50

Ref: TM-T31826

Fluperolone acetate

Controlled Product

CAS: 2119-75-7

Fluperolone acetate is a synthetic steroid that has been used as an anti-inflammatory agent. It is a potent corticosteroid and has been shown to inhibit the growth of microorganisms, such as bacteria and fungi. Fluperolone acetate does not cross the blood-brain barrier into the central nervous system, so it can be used for the treatment of inflammatory diseases in the eye without affecting vision. This drug also has been shown to reduce choroidal neovascularization in patients with age-related macular degeneration. Some biodegradable implants have been made from fluoropolymers, which are biocompatible polymers that are degraded by hydrolysis or enzymatic action in vivo. These implants may provide a sealant for use in surgical procedures and for treating cavities.

Formula: C₂₄H₃₁FO₆

Purity: Min. 95%

Molecular weight: 434.5 g/mol

Ref: 3D-FF23501