CAS 211914-51-1

Dabigatran

Description:

Dabigatran is an oral anticoagulant medication primarily used for the prevention and treatment of thromboembolic disorders, such as atrial fibrillation and deep vein thrombosis. It functions as a direct thrombin inhibitor, which means it directly inhibits the activity of thrombin, an enzyme crucial for blood clot formation. The chemical formula of dabigatran is C19H21N7O5S, and it features a unique structure that includes a carboxylic acid group, an amine group, and a sulfonamide moiety. Dabigatran is characterized by its high bioavailability and rapid onset of action, making it effective for managing clotting disorders. It is typically administered as a prodrug, dabigatran etexilate, which is converted into its active form in the body. The substance is known for its predictable pharmacokinetics, allowing for fixed dosing without the need for routine monitoring of anticoagulation levels, unlike traditional anticoagulants such as warfarin. However, it is essential to consider potential side effects, including bleeding risks, and to use it under medical supervision.

Formula: C₂₅H₂₅N₇O₃

InChI: InChI=1/C25H25N7O3/c1-31-20-10-7-17(25(35)32(13-11-23(33)34)21-4-2-3-12-28-21)14-19(20)30-22(31)15-29-18-8-5-16(6-9-18)24(26)27/h2-10,12,14,29H,11,13,15H2,1H3,(H3,26,27)(H,33,34)

InChI key: InChIKey=YBSJFWOBGCMAKL-UHFFFAOYSA-N

SMILES: CN1C=2C(=CC(C(N(CCC(O)=O)C3=CC=CC=N3)=O)=CC2)N=C1CNC4=CC=C(C(=N)N)C=C4

Synonyms:

• 3-[[2-[[(4-Carbamimidoylphenyl)Amino]Methyl]-1-Methyl-Benzoimidazole-5-Carbonyl]-Pyridin-2-Yl-Amino]Propanoic Acid
• Bibr 953
• Bibr 953Zw
• Dabigatran
• N-(2-(4-(N-(Hexyloxycarbonyl)Amidino)Phenylaminomethyl)-1-Methyl-1H-Benzimidazol-5-Ylcarbonyl)-N-(2-Pyridyl)-Beta-Alanine Ethyl Ester
• N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine
• beta-alanine, N-[[2-[[[4-(aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-
• β-Alanine, N-[[2-[[[4-(aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-
• N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-ben...
• N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine
• Dabiga group
• BIBR953;BIBR 953;BIBR-953
• Dabigatran etexilate impurity1513
• 3-[[2-[[(4-carbaMiMidoylphenyl)aMino]Methyl]-1-Met
• BIBR 953 (Dabigatran, Pradaxa)
• Dabigatran(BIB-953
• Dabigatran Q: What is the CAS Number of
• BIB-953
• 3-(2-((4-carbamimidoylphenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoic acid
• BIBR 953(Dabigatran)
• Dabigatran Etexilate Mesilate
• Dabigatran etexilate-1
• Dabigatran base
• 3-[[2-[[(4-carbaMiMidoylphenyl)aMino]Methyl]-1-Methyl-benzoiMidazole-5-carbonyl]-pyridin-2-yl-aMino]
• 3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic
• Dabigatran3-(2-((4-carbamimidoylphenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoic acid
• Dabigatran Ester Impurity B
• Dabigatran API
• BIBR 953;BIBR 953ZW;BIBR953;BIB-953
• Dabigatran Impurity U
• 3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic acid
• 3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic acid Dabigatran (BIBR 953)
• Dabigatran (Acid)
• ethyl 3-(2-(((4-(N'-((hexan-2-yloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate
• N-[[2-[[[4-(AMinoiMinoMethyl)phenyl]aMino]Methyl]-1-Methyl-1H-benzo[d]iMidazol-5-yl]carbonyl]-N-pyridin-2-yl-beta-alanine
• DabigatranQ: What is
• Dabigatran (BIBR 953)
• Dabigatran etexilate impurity189
• Dabigatran Impurity b
• N- (2-{ (4-carbaMiMidoylphenyl)aMino Methyl}-1-Met
• Dabigatran Q: What are the applications of
• Dabigatran Q: What is the storage condition of
• Dabigatran USP/EP/BP
• CS-1864
• N-[(2-{[(4-carbaMiMidoylphenyl)aMino]Methyl}-1-Methyl-1HbenziMidazol-

3-[1-(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-1,3-benzodiazol-5-yl)-N-(pyridin-2-yl)formamido]propanoic acid

CAS: 211914-51-1

Formula: C₂₅H₂₅N₇O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 471.5111

Ref: IN-DA00I41W

3-(2-(((4-Carbamimidoylphenyl)Amino)Methyl)-1-Methyl-N-(Pyridin-2-Yl)-1H-Benzo[D]Imidazole-5-Carboxamido)Propanoic Acid

CAS: 211914-51-1

3-(2-(((4-Carbamimidoylphenyl)Amino)Methyl)-1-Methyl-N-(Pyridin-2-Yl)-1H-Benzo[D]Imidazole-5-Carboxamido)Propanoic Acid

Purity: 98%

Molecular weight: 471.51g/mol

Ref: 54-OR1010625

Dabigatran

CAS: 211914-51-1

Formula: C₂₅H₂₅N₇O₃

Color and Shape: White To Off-White Solid

Molecular weight: 471.52

Ref: 4Z-D-591

Dabigatran-13C-d3

CAS: 211914-51-1

Formula: C₂₄₁₃CH₂₂D₃N₇O₃

Color and Shape: White To Off-White Solid

Molecular weight: 475.53

Ref: 4Z-D-59109

Dabigatran

CAS: 211914-51-1

Dabigatran

Purity: ≥95%

Molecular weight: 471.51g/mol

Ref: 54-BUP05533

N-Nitroso Dabigatran Etexilate-13C-d3

CAS: 211914-51-1

Formula: C₃₃₁₃CH₃₇D₃N₈O₆

Color and Shape: White To Off-White Solid

Molecular weight: 660.75

Ref: 4Z-D-59138

Dabigatran

CAS: 211914-51-1

Formula: C₂₅H₂₅N₇O₃

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 471.52

Ref: 3B-D5902

Dabigatran

CAS: 211914-51-1

Color and Shape: Neat

Ref: 86-MM3522.02

Dabigatran

CAS: 211914-51-1

Dabigatran (BIBR 953ZW), a thrombin inhibitor, prevents thrombus formation, reducing stroke and embolism risk in nonvalvular atrial fibrillation patients.

Formula: C₂₅H₂₅N₇O₃

Purity: 97.44% - 98.7%

Color and Shape: Tan Solid

Molecular weight: 471.51

Ref: TM-T6295

Dabigatran

CAS: 211914-51-1

Applications Nonpeptide, direct thrombin inhibitor. Antithrombotic.
References Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002), Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002), Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005),

Formula: C₂₅H₂₅N₇O₃

Color and Shape: Neat

Molecular weight: 471.51

Ref: TR-D100090

Dabigatran-d7 (>90%)

Controlled Product

CAS: 211914-51-1

Applications Dabigatran-d7, is the labeled analogue of Dabigatran (D100090), Nonpeptide, direct thrombin inhibitor. Antithrombotic.
References Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002), Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002), Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005),

Formula: C₂₅H₁₈D₇N₇O₃

Color and Shape: Neat

Molecular weight: 478.55

Ref: TR-D100093

Dabigatran

CAS: 211914-51-1

Formula: C₂₅H₂₅N₇O₃

Molecular weight: 471.51

Ref: ST-EA-CP-D5003

Dabigatran

CAS: 211914-51-1

Dabigatran is an oral prodrug that is converted to dabigatran etexilate by esterases in the blood. Dabigatran etexilate is an anticoagulant that inhibits thrombin formation and also prevents the conversion of fibrinogen to fibrin. The drug is used for the prevention of stroke or embolism in people with atrial fibrillation, as well as treatment and prevention of deep venous thrombosis and pulmonary embolism. Dabigatran etexilate has a long half-life of 15-20 hours, meaning that it can be administered once daily. There are two analytical methods for measuring dabigatran concentrations in plasma: one based on the activity of the drug's main metabolite (dabigatran etexilate) and another based on both dabigatran and its active metabolite (dabigatran etexil

Formula: C₂₅H₂₅N₇O₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 471.51 g/mol

Ref: 3D-FD32710

DABIGATRAN

CAS: 211914-51-1

Purity: 98%

Molecular weight: 471.5209961

Ref: 10-F799805