CAS 211915-06-9

Dabigatran etexilate

Description:

Dabigatran etexilate is an oral anticoagulant medication primarily used for the prevention and treatment of thromboembolic disorders, such as deep vein thrombosis and pulmonary embolism. It is a prodrug that is converted in the body to its active form, dabigatran, which directly inhibits thrombin, a key enzyme in the coagulation cascade. The substance is characterized by its relatively high bioavailability and rapid onset of action, making it effective for managing blood clot risks. Dabigatran etexilate is typically administered in capsule form and is known for its predictable pharmacokinetics, which allows for fixed dosing without the need for routine monitoring of coagulation parameters, unlike traditional anticoagulants such as warfarin. Its safety profile includes a risk of bleeding, which is a common concern with anticoagulants, and it is contraindicated in patients with certain renal impairments. Overall, dabigatran etexilate represents a significant advancement in anticoagulation therapy, offering convenience and efficacy for patients at risk of thrombotic events.

Formula: C₃₄H₄₁N₇O₅

InChI: InChI=1S/C34H41N7O5/c1-4-6-7-10-21-46-34(44)39-32(35)24-12-15-26(16-13-24)37-23-30-38-27-22-25(14-17-28(27)40(30)3)33(43)41(20-18-31(42)45-5-2)29-11-8-9-19-36-29/h8-9,11-17,19,22,37H,4-7,10,18,20-21,23H2,1-3H3,(H2,35,39,44)

InChI key: InChIKey=KSGXQBZTULBEEQ-UHFFFAOYSA-N

SMILES: CN1C=2C(=CC(C(N(CCC(OCC)=O)C3=CC=CC=N3)=O)=CC2)N=C1CNC4=CC=C(C(NC(OCCCCCC)=O)=N)C=C4

Synonyms:

• Alanine,N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-,ethyl ester
• Bibr-1048
• Bibr-1048Ms
• Dabigatran etexilate
• Dabigatran etexilate mesylate base
• Dabigatran free base
• N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-Alanine, ethyl ester
• Pradaxa
• Prazaxa
• ethyl N-[(2-{[(4-{[(hexyloxy)carbonyl]carbamimidoyl}phenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alaninate
• β-Alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester

Dabigatran Etexilate

CAS: 211915-06-9

Formula: C₃₄H₄₁N₇O₅

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 627.75

Ref: 3B-D5904

Dabigatran etexilate

CAS: 211915-06-9

Dabigatran etexilate (BIBR 1048) is a thrombin inhibitor, which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation.

Formula: C₃₄H₄₁N₇O₅

Purity: 98.19% - 99.98%

Color and Shape: White Powder

Molecular weight: 627.73

Ref: TM-T0389

Dabigatran etexilate

CAS: 211915-06-9

Dabigatran etexilate

Purity: ≥98%

Molecular weight: 627.73g/mol

Ref: 54-BUP14418

Dabigatran etexilate

CAS: 211915-06-9

Dabigatran etexilate

Purity: 99%

Molecular weight: 627.74g/mol

Ref: 54-OR1028277

Dabigatran Etexilate

CAS: 211915-06-9

Formula: C₃₄H₄₁N₇O₅

Color and Shape: White To Off-White Solid

Molecular weight: 627.75

Ref: 4Z-D-593

Dabigatran Etexilate-d13(hexyloxy-d13)

CAS: 211915-06-9

Purity: 98 atom % D

Color and Shape: White To Off White Solid

Molecular weight: 640.82

Ref: 3U-D7630

Dabigatran-d4 Etexilate

CAS: 211915-06-9

Formula: C₃₄H₃₇N₇O₅D₄

Molecular weight: 631.77

Ref: 4Z-D-5955

Dabigatran etexilate

CAS: 211915-06-9

Formula: C₃₄H₄₁N₇O₅

Purity: ≥ 98.0%

Color and Shape: White to almost white powder or crystals

Molecular weight: 627.73

Ref: 7W-GP5669

Dabigatran Etexilate

Controlled Product

CAS: 211915-06-9

Applications Dabigatran Etexilate is an oral anticoagulant and direct thrombin inhibitor.
References Mangiafico, R. et al.: Curr. Med. Chem., 19, 4688 (2012); Hu, Z. et al.: Anal. Bioanal. Chem., 405, 1695 (2013);

Formula: C₃₄H₄₁N₇O₅

Color and Shape: Neat

Molecular weight: 627.73

Ref: TR-D100140

Dabigatran Etexilate-d11

Controlled Product

CAS: 211915-06-9

Stability Hygroscopic
Applications Labeled Dabigatran Etexilate-d11, an oral anticoagulant and direct thrombin inhibitor.
References Mangiafico, R. et al.: Curr. Med. Chem., 19, 4688 (2012); Hu, Z. et al.: Anal. Bioanal. Chem., 405, 1695 (2013);

Formula: C₃₄H₃₀D₁₁N₇O₅

Color and Shape: Neat

Molecular weight: 638.8

Ref: TR-D100142

Dabigatran etexilate - Bio-X ™

CAS: 211915-06-9

Dabigatran is an anticoagulant that is used for the treatment of atrial fibrillation and prevention of venous thromboembolic events. It is a drug that acts as an inhibitor of the enzyme thrombin. Dabigatran inhibits platelet activation and aggregation, which reduces the risk of stroke or other vascular events. Dabigatran is a prodrug and does not have any activity in its active form.

Formula: C₃₄H₄₁N₇O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 627.73 g/mol

Ref: 3D-BD164344

Dabigatran etexilate

CAS: 211915-06-9

Inhibits thrombin and trypsin; anti-thrombotic

Formula: C₃₄H₄₁N₇O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 627.73 g/mol

Ref: 3D-FD64991