CAS 21202-05-1

N-1H-Benzimidazol-2-ylacetamide

Description:

N-1H-Benzimidazol-2-ylacetamide, with the CAS number 21202-05-1, is an organic compound characterized by its benzimidazole core, which is a bicyclic structure containing both benzene and imidazole rings. This compound typically exhibits properties such as being a white to off-white solid, and it is soluble in polar solvents like water and alcohols, depending on the specific conditions. The presence of the acetamide functional group contributes to its potential as a ligand in coordination chemistry and its utility in biological applications, including antimicrobial and anticancer activities. The compound may also participate in hydrogen bonding due to the amide group, influencing its reactivity and interaction with other molecules. Its structural features allow for various modifications, making it a subject of interest in medicinal chemistry and drug design. As with many benzimidazole derivatives, it may exhibit a range of biological activities, making it valuable in pharmaceutical research.

Formula: C₉H₉N₃O

InChI: InChI=1S/C9H9N3O/c1-6(13)10-9-11-7-4-2-3-5-8(7)12-9/h2-5H,1H3,(H2,10,11,12,13)

InChI key: InChIKey=BECUBVOEPSAYDH-UHFFFAOYSA-N

SMILES: N(C(C)=O)C=1NC=2C(N1)=CC=CC2

Synonyms:

• 2-(Acetylamino)benzimidazole
• 2-Acetamidobenzimidazole
• Acetamide, N-2-benzimidazolyl-
• N-(2-Benzimidazolyl)acetamide
• N-1H-Benzimidazol-2-ylacetamide
• acetamide, N-1H-benzimidazol-2-yl-

N-(1H-1,3-Benzodiazol-2-yl)acetamide

CAS: 21202-05-1

N-(1H-1,3-Benzodiazol-2-yl)acetamide is a hydrophilic molecule that has been shown to be active against helminths. It is used as an experimental drug for the treatment of schistosomiasis. N-(1H-1,3-Benzodiazol-2-yl)acetamide binds to the nuclear membrane and prevents the formation of hydrogen bonds with cytosine residues. This leads to a disruption in the helical structure of DNA and causes cell death. The compound also inhibits protein synthesis by binding to ribosomes and inhibiting peptide bond formation. In addition, N-(1H-1,3-Benzodiazol-2-yl)acetamide has been shown to have antimicrobial activity against bacteria and fungi.
The profile of this molecule can be altered by changing its substituents on benzene ring or cyclopropane ring. It can also be modified by altering the

Formula: C₉H₉N₃O

Purity: Min. 95%

Molecular weight: 175.19 g/mol

Ref: 3D-WAA20205