CAS 212069-94-8

SuMatriptan N-Oxide

Description:

Sumatriptan N-Oxide, identified by its CAS number 212069-94-8, is a chemical compound related to sumatriptan, a medication commonly used to treat migraines. As a derivative, Sumatriptan N-Oxide features an N-oxide functional group, which can influence its pharmacological properties and metabolic stability. This compound is typically characterized by its molecular structure, which includes a triptan core, known for its ability to selectively bind to serotonin receptors, particularly the 5-HT_1B and 5-HT_1D subtypes. The presence of the N-oxide group may affect its solubility, bioavailability, and overall efficacy compared to its parent compound. In terms of physical properties, it may exhibit distinct melting and boiling points, as well as specific spectral characteristics in techniques such as NMR and mass spectrometry. While detailed toxicity and safety profiles may not be extensively documented, compounds in this class are generally evaluated for their therapeutic potential and side effects in clinical settings.

Formula: C₁₄H₂₀N₃O₃S

Synonyms:

• N,N-Dimethyl-2-[5-[(methylsulphamoyl)methyl]-1H-indol-3-yl] ethanamine N-oxide
• SuMatriptan EP IMpurity D
• SuMatriptan N-Oxide
• SuMatriptan Succinate IMpurity – D (EP/BP)
• GR 112504
• 3-[2-(DiMethyloxidoaMino)ethyl]-N-Methyl-1H-indole-5-MethanesulfonaMide

Sumatriptan N-Oxide ([3-[2-(Dimethylamino-N-oxide)ethyl]-1H-indol-5-yl]-N-methylmethanesulfonamide)

CAS: 212069-94-8

Sulfonamides, nesoi

Formula: C₁₄H₂₁N₃O₃S

Color and Shape: White Solid

Molecular weight: 311.13036

Ref: 45-1A08360

Sumatriptan EP Impurity D (Sumatriptan N-Oxide)

CAS: 212069-94-8

Formula: C₁₄H₂₁N₃O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 311.40

Ref: 4Z-S-115

Sumatriptan EP Impurity D

CAS: 212069-94-8

Formula: C₁₄H₂₁N₃O₃S

Molecular weight: 311.40

Ref: ST-EA-CP-S13004

Sumatriptan N-Oxide

Controlled Product

CAS: 212069-94-8

Impurity Sumatriptan EP Impurity D
Stability Hygroscopic, Unstable in DMSO
Applications Sumatriptan N-Oxide (Sumatriptan EP Impurity D) is the degradation product of the antimigraine drug Sumatriptan (S810000).
References Xu, X. et al.: J. Pharmac. Biomed. Anal., 26, 367 (2001); Cheng, K.N. et al.: J. Pharmac. Biomed. Anal., 17, 399 (1998);

Formula: C₁₄H₂₁N₃O₃S

Color and Shape: Light Beige To Light Brown

Molecular weight: 311.40

Ref: TR-S810010

Sumatriptan N-oxide

CAS: 212069-94-8

Sumatriptan succinate is a triptan drug that is used to treat migraines. It has been shown to have high specificity for 5-HT1 receptors and low affinity for 5-HT2A, 5-HT2B, or 5-HT2C receptors. Sumatriptan succinate is rapidly metabolized by monoamine oxidase type A (MAO-A) in the liver to form sumatriptan. The major metabolite of sumatriptan is N-oxide (sumatriptan N-oxide). Sumatriptan N-oxide has been shown to be less potent than sumatriptan at inhibiting the release of inflammatory substances from mast cells in vitro.

Formula: C₁₄H₂₁N₃O₃S

Purity: Min. 95%

Molecular weight: 311.4 g/mol

Ref: 3D-FS27975