CAS 212141-51-0: Vatalanib dihydrochloride

Description: Vatalanib dihydrochloride is a small molecule that functions primarily as a tyrosine kinase inhibitor, targeting various receptor tyrosine kinases involved in angiogenesis and tumor growth. It is particularly noted for its potential in cancer therapy, as it inhibits pathways that promote vascular endothelial growth factor (VEGF) signaling, thereby disrupting the blood supply to tumors. The compound is characterized by its dihydrochloride salt form, which enhances its solubility and bioavailability. Vatalanib has been studied in clinical trials for various malignancies, including solid tumors, and exhibits a favorable pharmacokinetic profile. Its mechanism of action involves the selective inhibition of multiple kinases, which can lead to reduced tumor proliferation and metastasis. As with many pharmaceutical compounds, the safety and efficacy profile of Vatalanib dihydrochloride is subject to ongoing research, and its use is guided by clinical findings and regulatory approvals. Proper handling and storage conditions are essential to maintain its stability and effectiveness in therapeutic applications.

Formula: C₂₀H₁₇Cl₃N₄

InChI: InChI=1/C20H15ClN4.2ClH/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14;;/h1-12H,13H2,(H,23,25);2*1H

Synonyms:

• N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine dihydrochloride
• N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine hydrochloride
• N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride

Vatalanib Dihydrochloride

CAS: 212141-51-0

• Formula: C₂₀H₁₇Cl₃N₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 419.7348

Vatalanib dihydrochloride

CAS: 212141-51-0

• Purity: 99.9%
• Molecular weight: 419.73g/mol

Vatalanib, dihydrochloride salt

CAS: 212141-51-0

• Formula: C₂₀H₁₅ClN₄·2ClH
• Purity: 99.96% (Typical Value in Batch COA)
• Color and Shape: pale red solid
• Molecular weight: 419.73g/mol

Vatalanib dihydrochloride

CAS: 212141-51-0

Vatalanib dihydrochloride (PTK787 dihydrochloride)(IC50=37 nM) is an inhibitor of VEGFR2/KDR.

• Formula: C₂₀H₁₅ClN₄·2HCl
• Purity: 99.16%
• Color and Shape: White To Off-White Crystalline Powder
• Molecular weight: 419.73

Vatalanib Dihydrochloride

CAS: 212141-51-0

Applications Vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor. Antineoplastic. References Wood, J.M., et …

• Formula: C₂₀H₁₅ClN₄ClH
• Color and Shape: Neat
• Molecular weight: 419.73

Vatalanib dihydrochloride

CAS: 212141-51-0

VEGFR tyrosine kinase inhibitor

• Formula: C₂₀H₁₇Cl₃N₄
• Purity: Min. 95%
• Molecular weight: 419.73 g/mol