CAS 212141-51-0

Vatalanib dihydrochloride

Description:

Vatalanib dihydrochloride is a small molecule that functions primarily as a tyrosine kinase inhibitor, targeting various receptor tyrosine kinases involved in angiogenesis and tumor growth. It is particularly noted for its potential in cancer therapy, as it inhibits pathways that promote vascular endothelial growth factor (VEGF) signaling, thereby disrupting the blood supply to tumors. The compound is characterized by its dihydrochloride salt form, which enhances its solubility and bioavailability. Vatalanib has been studied in clinical trials for various malignancies, including solid tumors, and exhibits a favorable pharmacokinetic profile. Its mechanism of action involves the selective inhibition of multiple kinases, which can lead to reduced tumor proliferation and metastasis. As with many pharmaceutical compounds, the safety and efficacy profile of Vatalanib dihydrochloride is subject to ongoing research, and its use is guided by clinical findings and regulatory approvals. Proper handling and storage conditions are essential to maintain its stability and effectiveness in therapeutic applications.

Formula: C₂₀H₁₇Cl₃N₄

InChI: InChI=1/C20H15ClN4.2ClH/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14;;/h1-12H,13H2,(H,23,25);2*1H

SMILES: c1ccc2c(c1)c(Cc1ccncc1)nnc2Nc1ccc(cc1)Cl.Cl.Cl

Synonyms:

• N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine dihydrochloride
• N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine hydrochloride
• N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride

Vatalanib Dihydrochloride

CAS: 212141-51-0

Formula: C₂₀H₁₇Cl₃N₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 419.7348

Ref: IN-DA00BF56

Vatalanib dihydrochloride

CAS: 212141-51-0

Vatalanib dihydrochloride

Purity: ≥98%

Molecular weight: 419.73g/mol

Ref: 54-BUP11005

Vatalanib, dihydrochloride salt

CAS: 212141-51-0

Vatalanib, dihydrochloride salt

Formula: C₂₀H₁₅ClN₄·2ClH

Purity: 99.96% (Typical Value in Batch COA)

Color and Shape: pale red solid

Molecular weight: 419.73g/mol

Ref: 54-BIFK0044

Vatalanib dihydrochloride

CAS: 212141-51-0

Vatalanib dihydrochloride (PTK787 dihydrochloride)(IC50=37 nM) is an inhibitor of VEGFR2/KDR.

Formula: C₂₀H₁₅ClN₄·2HCl

Purity: 99.16%

Color and Shape: White To Off-White Crystalline Powder

Molecular weight: 419.73

Ref: TM-T6720

Vatalanib Dihydrochloride

Controlled Product

CAS: 212141-51-0

Applications Vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor. Antineoplastic.
References Wood, J.M., et al.: Cancer Res., 60, 2178 (2000), Morgan, B., et al.: J. Clin. Oncol., 21, 3955 (2003),

Formula: C₂₀H₁₅ClN₄·2ClH

Color and Shape: Neat

Molecular weight: 419.73

Ref: TR-V099500

Vatalanib dihydrochloride

CAS: 212141-51-0

VEGFR tyrosine kinase inhibitor

Formula: C₂₀H₁₇Cl₃N₄

Purity: Min. 95%

Molecular weight: 419.73 g/mol

Ref: 3D-FV28674