CAS 212141-54-3

Vatalanib

Description:

Vatalanib, with the CAS number 212141-54-3, is a small molecule that functions primarily as a tyrosine kinase inhibitor. It is designed to target and inhibit various receptor tyrosine kinases, which play a crucial role in processes such as cell proliferation, angiogenesis, and tumor growth. Vatalanib has shown potential in the treatment of various cancers by disrupting the signaling pathways that promote tumor development and metastasis. The compound is characterized by its ability to interfere with vascular endothelial growth factor (VEGF) signaling, thereby inhibiting angiogenesis, which is essential for tumor survival and growth. In terms of its chemical structure, Vatalanib contains specific functional groups that contribute to its biological activity and pharmacokinetic properties. The compound has been the subject of research in clinical trials, exploring its efficacy and safety in cancer therapy. As with many targeted therapies, the effectiveness of Vatalanib may vary based on the specific cancer type and the molecular characteristics of the tumor.

Formula: C₂₀H₁₅ClN₄

InChI: InChI=1/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)

InChI key: InChIKey=YCOYDOIWSSHVCK-UHFFFAOYSA-N

SMILES: N(C=1C2=C(C(CC=3C=CN=CC3)=NN1)C=CC=C2)C4=CC=C(Cl)C=C4

Synonyms:

• 1-Phthalazinamine, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-
• Cgp 79787
• N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine
• N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
• Pynasunate
• Vatalanib
• Vatalinib
• ZK 222584 (CPG-79787) 2HCL;PTK787 2HCL
• Vatalanib free base (PTK787 free base
• Vatalanib (PTK787)
• Vatalanib (PTK787) Dihydrochloride Base
• (4-Chloro-phenyl)-(4-pyridin-4-ylmethyl-phthalazin-1-yl)-amine
• anib (PTK787) 2HCL
• Vatalanib 2HCL
• PTK/ZK free base
• ZK-222584 free base)
• Vatalanib (free base)
• VATALANIB BASE
• Pynasunate, ZK222584, CGP-79787, PTK 787
• VataL
• PTK787 2HCl
• PTK787 FREE BASE; PTK/ZK FREE BASE; CGP-79787 FREE BASE; ZK-222584 FREE BASE
• PTK787 free base
• SORAFENIB BASE VATALANIB

1-Phthalazinamine,N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-

CAS: 212141-54-3

Formula: C₂₀H₁₅ClN₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 346.8129

Ref: IN-DA006YKS

Vatalanib free base

CAS: 212141-54-3

Vatalanib free base

Purity: ≥98%

Molecular weight: 346.81g/mol

Ref: 54-BUP10219

Vatalanib hydrochloride

CAS: 212141-54-3

Formula: C₂₀H₁₆Cl₂N₄

Molecular weight: 383.27

Ref: 7W-GP1506

Vatalanib free base

CAS: 212141-54-3

Vatalanib is a VEGFR2/KDR inhibitor (IC50: 37 nM).

Formula: C₂₀H₁₅ClN₄

Purity: 99.52%

Color and Shape: Solid

Molecular weight: 346.81

Ref: TM-T17219

Vatalanib

CAS: 212141-54-3

Vatalanib

Purity: 98%

Molecular weight: 346.81g/mol

Ref: 54-BIFK0006

Vatalanib HCl

CAS: 212141-54-3

VEGFR tyrosine kinase inhibitor

Formula: C₂₀H₁₅ClN₄•HCl

Purity: Min. 95%

Molecular weight: 383.27 g/mol

Ref: 3D-FV65204

Vatalanib

CAS: 212141-54-3

Vatalanib is a new anti-cancer drug that has been developed to inhibit the production of vascular endothelial growth factor (VEGF). It also inhibits cell factor (CF) and other biological properties. Vatalanib binds to the active site of the enzyme phosphatidylinositol 3-kinase, which is required for cell proliferation and survival. This binding leads to an increase in apoptosis, or programmed cell death, in cancer cells. Vatalanib has been shown to be effective against metastatic colorectal cancer and other solid tumours. The drug is not toxic to normal cells because it inhibits a protein that is required for activation of multiple pathways in these cells.

Formula: C₂₀H₁₅ClN₄

Purity: Min. 95%

Molecular weight: 346.8 g/mol

Ref: 3D-MIA14154