CAS 21238-36-8

8-oxoguanosine 5'-(tetrahydrogen triphosphate)

Description:

8-Oxoguanosine 5'-(tetrahydrogen triphosphate), commonly referred to as 8-oxo-GTP, is a modified nucleotide that plays a significant role in cellular processes, particularly in the context of oxidative stress and signaling pathways. This compound is characterized by the presence of an 8-oxo group on the guanine base, which is a marker of oxidative damage. The triphosphate moiety is crucial for its function in energy transfer and as a substrate for RNA synthesis. 8-oxo-GTP can participate in various biochemical reactions, including serving as a substrate for RNA polymerases and influencing the activity of certain GTP-binding proteins. Its presence in cells can indicate oxidative stress and has implications in various diseases, including cancer and neurodegenerative disorders. The compound is soluble in water, and its stability can be affected by environmental conditions, such as pH and temperature. Overall, 8-oxo-GTP is an important molecule in the study of cellular metabolism and the effects of oxidative damage on nucleic acids.

Formula: C₁₀H₂₀N₅O₁₈P₃

InChI: InChI=1/C10H11N5O6.3H3O4P/c11-9-13-6-3(7(19)14-9)12-10(20)15(6)8-5(18)4(17)2(1-16)21-8;3*1-5(2,3)4/h2,4-5,8,16-18H,1H2,(H2,11,14,19);3*(H3,1,2,3,4)/t2-,4-,5-,8-;;;/m1.../s1

SMILES: C([C@@H]1[C@H]([C@H]([C@H](N2C3=NC(=N)N=C(C3=NC2=O)O)O1)O)O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O

Guanosine 5'-(tetrahydrogen triphosphate), 7,8-dihydro-8-oxo-

CAS: 21238-36-8

Formula: C₁₀H₁₆N₅O₁₃P₃

Molecular weight: 507.181

Ref: IN-DA002TGQ

8-Hydroxy Guanosine 5'-Triphosphate Triethylammonium Salt

CAS: 21238-36-8

Stability Hygroscopic
Applications 8-Hydroxy Guanosine 5’-Triphosphate is an oxidized ribonucleotide induced mutations in cDNA, suggesting disturbance of genetic information during transcription and/or reverse transcription. It is a potential antiviral drug that cause mutations in genomic RNA.
References Taddei, F., et al.: Science, 278, 128 (1997), Kasai, H., et al.: Mutat. Res., 387, 147 (1997), Kamiya, H., et al.: Nucleic Acids Res., 231, 517 (2003),

Formula: C₁₀H₁₆N₅O₁₅P₃·(C₆H₁₅N)n

Color and Shape: Off White Solid

Molecular weight: 539.18 + x(101.19)

Ref: TR-H942780

8-Oxo-gtp 8-hydroxy-gtp

CAS: 21238-36-8

8-Oxo-GTP, also known as 8-Hydroxy-GTP, is a nucleotide analog, which is synthetically derived. It closely resembles the naturally occurring guanosine triphosphate (GTP) but contains a modified 8-hydroxy group, making it a valuable tool for studying oxidative damage and nucleotide modification processes.

Formula: C₁₀H₁₆N₅O₁₅P₃

Purity: Min. 95%

Molecular weight: 539.18 g/mol

Ref: 3D-WAA23836