CAS 2124269-77-6

Atropine-d5

Description:

Atropine-d5 is a deuterated form of atropine, a tropane alkaloid that is derived from plants such as belladonna. The "d5" designation indicates that five hydrogen atoms in the atropine molecule have been replaced with deuterium, a stable isotope of hydrogen. This modification enhances its utility in various analytical applications, particularly in nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry, where deuterated compounds can provide clearer signals and reduce background noise. Atropine itself is known for its anticholinergic properties, acting as a competitive antagonist of the muscarinic acetylcholine receptors, which makes it useful in medical settings for treating bradycardia, as an antidote for organophosphate poisoning, and for dilating pupils in ophthalmology. The deuterated version, Atropine-d5, retains these pharmacological properties while offering advantages in research and development, particularly in studies involving metabolic pathways and drug interactions. Its chemical structure and behavior in biological systems may be similar to that of non-deuterated atropine, but the presence of deuterium can influence its kinetics and dynamics in specific contexts.

Formula: C₁₇H₂₃NO₃

Synonyms:

• α-(HydroxyMethyl)benzeneacetic Acid-d5 (3-endo)-8-Methyl-8-azabicyclo[3.2.1]
• oct-3-yl Ester
• Atropine-d5
• Atropt-d5
• Atropisol-d5
• Atropin-d5
• (+/-)-HyoscyaMine-d5
• dl-HyoscyaMine-d5
• Tropine-d5 (+/-)-Tropate
• dl-Tropyl Tropate-d5

Atropine-d5

Controlled Product

CAS: 2124269-77-6

Stability Hygroscopic
Applications Labelled Atropine. Mydriatic; antispasmodic; used in preanesthetic medication.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Brown, R.V., et al.: Br. J. Pharmacol., 15, 170 (1960), Shutt, L.E., et al.: Anaesthesia, 34, 476 (1979), Hinderling, P.H., et al.: J. Pharm. Sci., 74, 703 (1985),

Formula: C₁₇H₁₈D₅NO₃

Color and Shape: Light Yellow Solid

Molecular weight: 294.4

Ref: TR-A794627