CAS 212631-67-9

PD184161

Description:

PD184161, with the CAS number 212631-67-9, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its role as a selective inhibitor of certain protein kinases. This compound is characterized by its ability to modulate specific signaling pathways, making it a subject of interest in cancer research and other therapeutic areas. PD184161 is known for its relatively high potency and selectivity, which can lead to reduced off-target effects compared to less selective inhibitors. Its chemical structure typically includes functional groups that contribute to its binding affinity and biological activity. Additionally, PD184161 has been studied for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion (ADME), which are crucial for evaluating its potential as a therapeutic agent. Overall, PD184161 represents a valuable tool in the exploration of targeted therapies, particularly in the context of diseases driven by aberrant kinase activity.

Formula: C₁₇H₁₃BrClF₂IN₂O₂

InChI: InChI=1S/C17H13BrClF2IN2O2/c18-11-6-10(17(25)24-26-7-8-1-2-8)16(15(21)14(11)20)23-13-4-3-9(22)5-12(13)19/h3-6,8,23H,1-2,7H2,(H,24,25)

InChI key: InChIKey=VJNZMSLGVUSPCF-UHFFFAOYSA-N

SMILES: N(C1=C(C(NOCC2CC2)=O)C=C(Br)C(F)=C1F)C3=C(Cl)C=C(I)C=C3

Synonyms:

• 5-Bromo-2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
• PD 184161
• Benzamide, 5-bromo-2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-
• 5-Bromo-2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide
• PF-1529483
• MEK1/2 Inhibitor IV - CAS 212631-67-9 - Calbiochem
• PF-3011370
• UK-287074
• MEK1/2 Inhibitor IV

PD 184161

CAS: 212631-67-9

Formula: C₁₇H₁₃BrClF₂IN₂O₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 557.5556

Ref: IN-DA006Y21

PD-184161

CAS: 212631-67-9

Formula: C₁₇H₁₃BrClF₂IN₂O₂

Molecular weight: 557.56

Ref: 7W-GK5404

PD184161

CAS: 212631-67-9

PD184161

Purity: ≥98%

Molecular weight: 557.56g/mol

Ref: 54-BUP12122

5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide

CAS: 212631-67-9

5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide

Purity: 99%

Molecular weight: 557.56g/mol

Ref: 54-PC108585

PD184161

CAS: 212631-67-9

PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].

Formula: C₁₇H₁₃BrClF₂IN₂O₂

Purity: 99.40%

Color and Shape: Solid

Molecular weight: 557.56

Ref: TM-T21635

PD184161

CAS: 212631-67-9

Purity: 99%

Molecular weight: 555.886

Ref: 10-F870362

PD-184161

Controlled Product

CAS: 212631-67-9

Applications PD-184161 is a novel mitogen-activated protein kinase kinase (MEK) inhibitor shown to exhibit antitumor effects and suppress MEK-extracellular signal-related kinase signaling activity and cell proliferation in human hepatocellular carcinoma cells and in human hepatocellular carcinoma xenografts.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yip-Schneider, M.T. et al.: J. Pharmacol. Exp. Therap., 329, 1063 (2009); Klein, P.J. et al.: Neoplasia, 8, 1 (2006); Yung, H.W. et al.: Biochem. Pharmacol., 68, 351 (2004);

Formula: C₁₇H₁₃BrClF₂IN₂O₂

Color and Shape: Neat

Molecular weight: 557.5556

Ref: TR-P218100

PD 184161

CAS: 212631-67-9

Inhibitor of MEK kinases

Formula: C₁₇H₁₃BrClF₂IN₂O₂

Purity: Min. 95%

Molecular weight: 557.56 g/mol

Ref: 3D-FP26779