CAS 212844-53-6

Purvalanol A

Description:

Purvalanol A is a selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK2 and CDK1, which play crucial roles in cell cycle regulation. This compound is characterized by its ability to interfere with the phosphorylation of target proteins, thereby influencing cellular proliferation and apoptosis. Purvalanol A is often utilized in research settings to study cell cycle dynamics and the effects of CDK inhibition on cancer cell growth. It is typically presented as a white to off-white solid and is soluble in organic solvents such as DMSO. The compound has a molecular formula that reflects its complex structure, which includes multiple functional groups that contribute to its biological activity. Due to its specificity and potency, Purvalanol A serves as a valuable tool in pharmacological studies and has potential implications in cancer therapy, where modulation of CDK activity can lead to therapeutic benefits. However, as with any chemical substance, proper handling and safety protocols should be observed during its use in laboratory settings.

Formula: C₁₉H₂₅ClN₆O

InChI: InChI=1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1

InChI key: InChIKey=PMXCMJLOPOFPBT-HNNXBMFYSA-N

SMILES: N(C1=C2C(N(C(C)C)C=N2)=NC(N[C@H](C(C)C)CO)=N1)C3=CC(Cl)=CC=C3

Synonyms:

• (2R)-2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methylbutan-1-ol
• (2R)-2-[[6-(3-Chloroanilino)-9-isopropyl-purin-2-yl]amino]-3-methyl-butan-1-ol
• (2R)-2-[[6-(3-Chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol
• (2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
• (R)-Purvalanol A
• 1-Butanol, 2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-, (2R)-
• Ng 60
• Purvalanol A

Purvalanol A

CAS: 212844-53-6

Formula: C₁₉H₂₅ClN₆O

Purity: 98%

Color and Shape: Solid

Molecular weight: 388.8944

Ref: IN-DA007QVU

Purvalanol A

CAS: 212844-53-6

Purvalanol A

Purity: ≥98%

Molecular weight: 388.89g/mol

Ref: 54-BUP10792

Purvalanol A

CAS: 212844-53-6

Formula: C₁₉H₂₅ClN₆O

Purity: (HPLC) ≥ 98.0%

Color and Shape: Light green powder

Molecular weight: 388.89

Ref: 7W-GK0611

Purvalanol A

CAS: 212844-53-6

Purvalanol A

Formula: C₁₉H₂₅ClN₆O

Purity: 99.76% (Typical Value in Batch COA)

Color and Shape: green solid

Molecular weight: 388.89g/mol

Ref: 54-BIFK0054

Purvalanol A

CAS: 212844-53-6

Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively.

Formula: C₁₉H₂₅ClN₆O

Purity: 98.13% - 99.68%

Color and Shape: Powder

Molecular weight: 388.89

Ref: TM-T2059

Purvalanol A

CAS: 212844-53-6

M02310 - Purvalanol A

Formula: C₁₉H₂₅ClN₆O

Purity: 98%

Molecular weight: 388.9

Ref: 10-M02310