CAS 21302-43-2

5-Amino-8-hydroxyquinoline dihydrochloride

Description:

5-Amino-8-hydroxyquinoline dihydrochloride is a chemical compound characterized by its quinoline structure, which features both amino and hydroxy functional groups. This compound typically appears as a crystalline solid and is soluble in water due to the presence of the dihydrochloride salt form, which enhances its solubility. It is often used in various applications, including as a reagent in analytical chemistry and as a potential therapeutic agent due to its biological activity. The amino group can participate in various chemical reactions, making it a versatile compound in synthetic organic chemistry. Additionally, the hydroxy group contributes to its ability to form hydrogen bonds, influencing its interactions in biological systems. Safety data indicates that, like many chemical substances, it should be handled with care, as it may pose health risks if ingested or inhaled. Proper laboratory practices should be followed when working with this compound to ensure safety and compliance with regulations.

Formula: C₉H₈N₂O·2ClH

InChI: InChI=1S/C9H8N2O.2ClH/c10-7-3-4-8(12)9-6(7)2-1-5-11-9;;/h1-5,12H,10H2;2*1H

InChI key: InChIKey=VTQDJAUGGZFPOI-UHFFFAOYSA-N

SMILES: NC=1C2=C(C(O)=CC1)N=CC=C2.Cl

Synonyms:

• 5-Amino-8-Hydroquinoline Dihydrochloride
• 5-Amino-8-Hydroxyquinoline Dihydrochloride
• 5-Amino-8-Hydroxyquinoline Dihydrochloride 97+%
• 5-Amino-8-Hydroxyquinoline2Hcl
• 5-Amino-8-Quinolinol Dihydrochloride
• 5-Aminoquinolin-8-Ol Dihydrochloride
• 8-Quinolinol, 5-Amino-, Dihydrochloride
• 8-Quinolinol, 5-amino-, hydrochloride (1:2)

5-Amino-8-hydroxyquinoline Dihydrochloride

CAS: 21302-43-2

Formula: C₉H₈N₂O·2HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: Orange to Amber to Dark red powder to crystal

Molecular weight: 233.09

Ref: 3B-A1005

5-Aminoquinolin-8-ol dihydrochloride 

CAS: 21302-43-2

Formula: C₉H₁₀Cl₂N₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 233.0945

Ref: IN-DA003MEN

5-Amino-8-hydroxyquinoline dihydrochloride

CAS: 21302-43-2

Formula: C₉H₈N₂O·2HCl

Purity: ≥ 98.0%

Color and Shape: Orange-yellow to dark brown powder, crystals or solid

Molecular weight: 233.09

Ref: 7W-GK2902

5-Amino-8-Quinolinol Dihydrochloride

CAS: 21302-43-2

5-Amino-8-Quinolinol Dihydrochloride

Purity: 98%

Molecular weight: 233.1g/mol

Ref: 54-OR1029258

5-Aminoquinolin-8-ol dihydrochloride

CAS: 21302-43-2

Formula: C₉H₁₀Cl₂N₂O

Purity: ≥98%

Color and Shape: Solid, Yellow red - Deep yellow red powder

Molecular weight: 233.09

Ref: 10-F242702

5-Amino-8-hydroxyquinoline dihydrochloride

CAS: 21302-43-2

5-Amino-8-hydroxyquinoline dihydrochloride (5-AQDH) is an anticancer drug that inhibits the activity of survivin, a protein that is overexpressed in cancer cells. It has been shown to be effective in vivo against melanoma tumor growth. 5-AQDH binds to the unpaired cysteine residues of the survivin molecule and inhibits its function by binding to the active site, blocking access to ATP and preventing DNA synthesis. The efficacy of 5-AQDH has been confirmed in vitro by studying the effect on cell viability and DNA synthesis, as well as by measuring plasma mass spectrometry data from melanoma patients. This drug is currently being investigated for its potential use as an anticancer agent.

Formula: C₉H₈N₂O•(HCl)₂

Purity: Min. 95%

Molecular weight: 212.63 g/mol

Ref: 3D-FA40514