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CAS 2132-62-9

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Lincomycin 2,7-diacetate

Description:
Lincomycin 2,7-diacetate is a semi-synthetic derivative of lincomycin, an antibiotic produced by the bacterium *Streptomyces lincolnensis*. This compound is characterized by its acetylation at the 2 and 7 positions of the lincomycin molecule, which enhances its stability and bioavailability. Lincomycin 2,7-diacetate exhibits antibacterial properties, particularly effective against Gram-positive bacteria and some anaerobic organisms. It functions by inhibiting bacterial protein synthesis, thereby preventing bacterial growth. The compound is typically administered via injection or orally, depending on the formulation. Its pharmacokinetics include good absorption and distribution in body tissues, with metabolism primarily occurring in the liver. Lincomycin 2,7-diacetate is also known for its potential side effects, which may include gastrointestinal disturbances and allergic reactions. As with other antibiotics, it is essential to use this compound judiciously to prevent the development of antibiotic resistance. Overall, lincomycin 2,7-diacetate serves as an important therapeutic agent in treating various bacterial infections.
Formula:C22H38N2O8S
InChI:InChI=1/C22H38N2O8S/c1-7-8-14-9-15(24(5)10-14)21(29)23-16(11(2)30-12(3)25)19-17(27)18(28)20(31-13(4)26)22(32-19)33-6/h11,14-20,22,27-28H,7-10H2,1-6H3,(H,23,29)/t11?,14?,15-,16?,17?,18?,19?,20?,22?/m0/s1
SMILES:CCCC1C[C@@H](C(=NC(C(C)OC(=O)C)C2C(C(C(C(O2)SC)OC(=O)C)O)O)O)N(C)C1
Synonyms:
  • [6-[2-Acetyloxy-1-[[(2S)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] acetate
  • methyl 2,7-di-O-acetyl-6,8-dideoxy-6-[(1-methyl-4-propyl-L-prolyl)amino]-1-thiooctopyranoside
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