CAS 2136247-12-4

MD-224

CAS: 2136247-12-4

MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.

Formula: C₄₈H₄₃Cl₂FN₆O₆

Purity: 99.07% - >99.99%

Color and Shape: Solid

Molecular weight: 889.8

Ref: TM-T11980

MD-224

CAS: 2136247-12-4

MD-224

Purity: ≥98%

Molecular weight: 889.8g/mol

Ref: 54-BUP01364

MD-224

CAS: 2136247-12-4

MD-224 is a small molecule that inhibits the function of the enzyme beta-secretase (BACE1). This protein is responsible for cleaving amyloid precursor protein (APP) to form beta-amyloid peptides. The inhibition of BACE1 has been shown to decrease the production of beta-amyloid, which may be an effective therapy for Alzheimer's Disease. MD-224 also inhibits cellular processes such as DNA repair and cell division. The compound has been validated in a xenograft tumor model and leukemia cells in vitro. A fossil sequence homologous to MD-224 has been identified in endogenous yeast, suggesting that it may have a biological function.

Formula: C₄₈H₄₃Cl₂FN₆O₆

Purity: Min. 95%

Molecular weight: 889.8 g/mol

Ref: 3D-LKD24712