CAS 213819-48-8

1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]ethyl]-, hydrochloride (1:1), (4S)-

Description:

1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]ethyl]-, hydrochloride (1:1), (4S)-, is a complex organic compound characterized by its unique bicyclic structure that incorporates both pyrano and indolizino moieties. This compound features multiple functional groups, including a hydroxy group and an ethyl substituent, which contribute to its solubility and reactivity. The presence of a hydrochloride salt form indicates that it is a protonated species, enhancing its stability and solubility in aqueous environments. The stereochemistry denoted by (4S) suggests specific spatial arrangements of atoms, which can influence its biological activity and interactions. This compound may exhibit pharmacological properties, potentially acting as a therapeutic agent, although specific biological activities would require further investigation. Its CAS number, 213819-48-8, allows for precise identification in chemical databases, facilitating research and application in various fields, including medicinal chemistry and drug development.

Formula: C₂₅H₂₇N₃O₄·ClH

InChI: InChI=1S/C25H27N3O4.ClH/c1-4-25(31)19-11-21-22-17(12-28(21)23(29)18(19)13-32-24(25)30)15(9-10-26-14(2)3)16-7-5-6-8-20(16)27-22;/h5-8,11,14,26,31H,4,9-10,12-13H2,1-3H3;1H/t25-;/m0./s1

InChI key: InChIKey=SJKBXKKZBKCHET-UQIIZPHYSA-N

SMILES: O=C1N2C(C=3C(C2)=C(CCNC(C)C)C=4C(N3)=CC=CC4)=CC5=C1COC(=O)[C@@]5(CC)O.Cl

Synonyms:

• (4S)-4-ethyl-4-hydroxy-11-{2-[(1-methylethyl)amino]ethyl}-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride
• (S)-4-Ethyl-4-hydroxy-11-(2-(isopropylamino)ethyl)-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride
• (S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione hydrochloride
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]ethyl]-, hydrochloride (1:1), (4S)-
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]ethyl]-, monohydrochloride, (4S)-
• Belotecan hydrochloride
• Ckd 602

Camtobell hydrochloride

CAS: 213819-48-8

Formula: C₂₅H₂₈ClN₃O₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 469.9605

Ref: IN-DA00C364

Belotecan hydrochloride

CAS: 213819-48-8

Belotecan hydrochloride

Purity: ≥95%

Molecular weight: 469.96g/mol

Ref: 54-BUP12070

(S)-4-Ethyl-4-Hydroxy-11-(2-(Isopropylamino)Ethyl)-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione Hydrochloride

CAS: 213819-48-8

(S)-4-Ethyl-4-Hydroxy-11-(2-(Isopropylamino)Ethyl)-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione Hydrochloride

Purity: 97%

Molecular weight: 469.96g/mol

Ref: 54-OR1024225

Belotecan hydrochloride

CAS: 213819-48-8

Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity

Formula: C₂₅H₂₈ClN₃O₄

Purity: 99.63% - ≥95%

Color and Shape: Solid

Molecular weight: 469.96

Ref: TM-T7551

Belotecan HCl

CAS: 213819-48-8

Formula: C₂₅H₂₇N₃O₄·HCl

Molecular weight: 433.51 36.46

Ref: 4Z-I-1845

Belotecan Hydrochloride

Controlled Product

CAS: 213819-48-8

Applications A novel camptothecin-derivative anti-tumor agent. CKD-602-related toxicities induced by IV infusion administration have not yet been evaluated, although the drug is more widely used in clinical settings.
References Hertzberg, R., et al.: J. Med. Chem., 32, 715 (1989), Hashimoto, H., et al.: Clin. Cancer Res., 1, 369 (19950, Dahut, W., et al.: J. Clin. Oncol., 14, 1236 (1996),

Formula: C₂₅H₂₇N₃O₄·ClH

Color and Shape: Neat

Molecular weight: 469.96

Ref: TR-B131300

Belotecan hydrochloride

CAS: 213819-48-8

Topoisomerase I inhibitor

Formula: C₂₅H₂₈ClN₃O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 469.96 g/mol

Ref: 3D-FC152239