CAS 2140-76-3

2'-O-methyluridine

Description:

2'-O-methyluridine is a modified nucleoside that features a methyl group attached to the 2' hydroxyl position of the ribose sugar in uridine. This modification enhances the stability of RNA molecules and can influence their biological activity. The chemical formula of 2'-O-methyluridine is C10H13N2O5, and it is classified as a pyrimidine nucleoside. It is soluble in water and exhibits properties typical of nucleosides, such as the ability to participate in hydrogen bonding and base pairing. This compound is often used in biochemical research and therapeutic applications, particularly in the study of RNA structure and function, as well as in the development of antiviral agents. The presence of the methyl group can also affect the interaction of the nucleoside with enzymes and other biomolecules, making it a valuable tool in molecular biology. Overall, 2'-O-methyluridine serves as an important component in the field of nucleic acid chemistry and has implications in various biotechnological applications.

Formula: C₁₀H₁₄N₂O₆

InChI: InChI=1/C10H14N2O6/c1-17-8-7(15)5(4-13)18-9(8)12-3-2-6(14)11-10(12)16/h2-3,5,7-9,13,15H,4H2,1H3,(H,11,14,16)/t5-,7-,8-,9-/m1/s1

InChI key: InChIKey=SXUXMRMBWZCMEN-ZOQUXTDFSA-N

SMILES: O(C)[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)NC(=O)C=C2

Synonyms:

• 2''-O-Methyluridine Crystalline
• 2'-O-Methyluridine (Chiral)
• O²′-Methyluridine
• Uridine, 2′-O-methyl-
• 2′-O-Methyluridine
• O2′-Methyluridine
• 1: PN: WO2023049218 PAGE: 366 claimed sequence
• -2'-O-METHYLURIDINE

2'-O-Methyluridine

CAS: 2140-76-3

Formula: C₁₀H₁₄N₂O₆

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 258.23

Ref: 3B-M2290

2'-O-Methyluridine, 99%

CAS: 2140-76-3

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₀H₁₄N₂O₆

Purity: 99%

Molecular weight: 258.23

Ref: 02-J64897

1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

CAS: 2140-76-3

Formula: C₁₀H₁₄N₂O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 258.2280

Ref: IN-DA0037V3

2''-O-Methyl uridine

CAS: 2140-76-3

Formula: C₁₀H₁₄N₂O₆

Molecular weight: 258.23

Ref: 7W-GC2862

2'-O-Methyluridine

CAS: 2140-76-3

2'-O-Methyluridine

Purity: 99%

Color and Shape: Solid

Molecular weight: 258.23g/mol

Ref: 54-OR60199

2′-O-Methyluridine

CAS: 2140-76-3

2′-O-Methyluridine

Purity: ≥98%

Molecular weight: 258.23g/mol

Ref: 54-BUP16476

2'-O-Methyluridine

CAS: 2140-76-3

Formula: C₁₀H₁₄N₂O₆

Molecular weight: 258.23

Ref: 4Z-U-0151

2′-O-Methyluridine

CAS: 2140-76-3

2′-O-Methyluridine is a natural product that found in RNA such as rRNA, snRNA, snoRNA and tRNA in Archaea, Bacteria, and Eukaryota.

Formula: C₁₀H₁₄N₂O₆

Purity: 99.6%

Color and Shape: Solid

Molecular weight: 258.23

Ref: TM-TN7106

2'-O-Methyl Uridine-d3

Controlled Product

CAS: 2140-76-3

Applications 2'-O-Methyl Uridine-d3 is an isotope labelled compound of 2'-O-Methyl Uridine (M338200), a uridine analog used for the preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.
References Gratzner, H., et al.: Science, 218, 474 (1982), Jarvis, T., et al.: J. Biol. Chem., 271, 29107 (1996), Pavco, P., et al.: Clin. Cancer Res., 6, 2094 (2000),

Formula: C₁₀D₃H₁₁N₂O₆

Color and Shape: Neat

Molecular weight: 261.246

Ref: TR-M338202

2'-O-Methyl Uridine

Controlled Product

CAS: 2140-76-3

Applications Uridine analog. Used for preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.
References Gratzner, H., et al.: Science, 218, 474 (1982), Jarvis, T., et al.: J. Biol. Chem., 271, 29107 (1996), Pavco, P., et al.: Clin. Cancer Res., 6, 2094 (2000),

Formula: C₁₀H₁₄N₂O₆

Color and Shape: Neat

Molecular weight: 258.23

Ref: TR-M338200

1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

CAS: 2140-76-3

Formula: C₁₀H₁₄N₂O₆

Purity: 95%

Color and Shape: Solid

Molecular weight: 258.23

Ref: 10-F212232

2'-O-Methyluridine

CAS: 2140-76-3

2'-O-Methyluridine is a chemical compound that is used in the synthesis of RNA. It is an analog of uridine and has been shown to have antiviral and anticancer properties. 2'-O-Methyluridine inhibits protein synthesis by competing with uridine for the active site of the enzyme ribonucleotide reductase, which converts ribonucleotides to dNMPs. This compound also inhibits RNA synthesis by disrupting the pairing of adenine and cytosine residues in RNA strands. 2'-O-Methyluridine has been shown to inhibit growth in some types of cancer cells, including colorectal adenocarcinoma cells. It may also be useful as a chemotherapeutic agent against HIV, as it inhibits virus replication by inhibiting reverse transcription and DNA synthesis.

Formula: C₁₀H₁₄N₂O₆

Purity: Min. 98 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 258.23 g/mol

Ref: 3D-NM04259