CAS 2140-77-4
:N2-Methylguanosine
Description:
N2-Methylguanosine is a modified nucleoside that plays a significant role in various biological processes, particularly in RNA metabolism. It is characterized by the presence of a methyl group attached to the nitrogen atom at the 2-position of the guanine base. This modification can influence the stability and function of RNA molecules, affecting processes such as translation and RNA splicing. N2-Methylguanosine is often found in tRNA and rRNA, where it contributes to the structural integrity and proper functioning of these essential biomolecules. The presence of this modification can also impact the interaction of RNA with proteins and other nucleic acids, thereby influencing gene expression and regulation. In terms of its chemical properties, N2-Methylguanosine is soluble in water and exhibits typical nucleoside behavior in biochemical reactions. Its study is important for understanding the complexities of RNA biology and the regulatory mechanisms that govern cellular processes.
Formula:C11H15N5O5
InChI:InChI=1S/C11H15N5O5/c1-12-11-14-8-5(9(20)15-11)13-3-16(8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15,20)/t4-,6-,7-,10-/m1/s1
InChI key:InChIKey=SLEHROROQDYRAW-KQYNXXCUSA-N
SMILES:O[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=C(NC)N3)O[C@H](CO)[C@H]1O
Synonyms:- 2-(methylamino)-9-pentofuranosyl-3,9-dihydro-6H-purin-6-one
- 2-Methylguanosine
- 7-Methylguanosine
- Guanosine, N-methyl-
- N(2)-Methylguanosine
- N-methylguanosine
- N<sup>2</sup>-Methylguanine riboside
- N<sup>2</sup>-Methylguanosine
- N2-Methylguanosine
- N2-Methylguanine riboside
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 8 products.
9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-2-(Methylamino)-1H-Purin-6(9H)-One
CAS:9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-2-(Methylamino)-1H-Purin-6(9H)-OnePurity:95%Molecular weight:297.27g/molN2-Methylguanosine
CAS:Formula:C11H15N5O5Purity:≥ 97.0%Color and Shape:White to off-white powderMolecular weight:297.27N2-Methylguanosine
CAS:Formula:C11H15N5O5Purity:>95.0%(HPLC)(qNMR)Color and Shape:White to Light yellow powder to crystalMolecular weight:297.27N2-Methylguanosine
CAS:<p>N2-methylguanosine is a modified nucleoside of tRNA that occurs at several specific locations in many tRNA's</p>Formula:C11H15N5O5Purity:97.77%Color and Shape:SolidMolecular weight:297.27N2-Methylguanosine
CAS:<p>N2-Methylguanosine is an antiviral agent that has been modified from the natural form of guanosine. It has been shown to inhibit the replication of a number of viruses, including herpes simplex virus type 1 and type 2, cytomegalovirus, and others. N2-Methylguanosine also inhibits the growth of tumor cells in vitro and in vivo. In addition to its antiviral activity, it has been found to have anticancer effects in preclinical studies. N2-Methylguanosine has also been shown to inhibit diphosphate kinase (DPK) and phosphoramidite synthase (PAS), enzymes that are involved in DNA replication.<br>N2-Methylguanosine is synthesized by reacting 5'-monophosphate nucleosides with 2-methyl-4-(4-nitrophenyl)thiourea followed by purification by ion exchange chromatography.</p>Formula:C11H15N5O5Purity:Min. 95 Area-%Color and Shape:PowderMolecular weight:297.27 g/mol
