CAS 214287-88-4

(-)-6-Chloro-4(S)-(2-cyclopropylethynyl)-4-(trifluoromethyl)-3,4-dihydro-1H-quinazolin-2-one

Description:

The chemical substance known as (-)-6-Chloro-4(S)-(2-cyclopropylethynyl)-4-(trifluoromethyl)-3,4-dihydro-1H-quinazolin-2-one, with the CAS number 214287-88-4, is a synthetic organic compound characterized by its complex structure, which includes a quinazolinone core. This compound features a chloro substituent at the 6-position and a trifluoromethyl group at the 4-position, contributing to its unique chemical properties. The presence of a cyclopropylethynyl group enhances its potential for biological activity, making it of interest in medicinal chemistry. The stereochemistry indicated by the (S) configuration suggests specific spatial arrangements that can influence the compound's interactions with biological targets. Its molecular structure suggests potential applications in pharmaceuticals, particularly in the development of drugs targeting specific receptors or enzymes. Additionally, the trifluoromethyl group is known to enhance lipophilicity and metabolic stability, which are desirable traits in drug design. Overall, this compound exemplifies the intricate relationship between molecular structure and biological function in the field of chemistry.

Formula: C₁₄H₁₀ClF₃N₂O

InChI: InChI=1/C14H10ClF3N2O/c15-9-3-4-11-10(7-9)13(14(16,17)18,20-12(21)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H2,19,20,21)/t13-/m0/s1

SMILES: C1CC1C#C[C@]1(c2cc(ccc2N=C(N1)O)Cl)C(F)(F)F

Synonyms:

• Dpc-961
• Dmp-961
• (4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

(4S)-6-Chloro-4-(2-cyclopropylethynyl)-3,4-dihydro-4-(trifluoromethyl)-2(1H)-quinazolinone

CAS: 214287-88-4

Formula: C₁₄H₁₀ClF₃N₂O

Color and Shape: Solid

Molecular weight: 314.6902

Ref: IN-DA0037L7

DPC 961

Controlled Product

CAS: 214287-88-4

Applications DPC 961 is a novel anti-HIV drug used in the treatment of the affliction. Used as a non-nucleoside reverse-transcriptase inhibitor, it helps control the replication of genetic material.
References Corbett, J. et al.: J. Med. Chem., 43, 2019 (2000); Jiang, B. et al.: Angew. Chem. Int. Ed., 43, 216 (2003);

Formula: C₁₄H₁₀ClF₃N₂O

Color and Shape: Neat

Molecular weight: 314.69

Ref: TR-D585800

DPC 961-d4

Controlled Product

CAS: 214287-88-4

Formula: C₁₄D₄H₆ClF₃N₂O

Color and Shape: Neat

Molecular weight: 318.715

Ref: TR-D585802

DPC-961

CAS: 214287-88-4

DPC-961, a reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection.

Formula: C₁₄H₁₀ClF₃N₂O

Color and Shape: Solid

Molecular weight: 314.69

Ref: TM-T27203