CAS 214287-99-7

(E)-6-Chloro-4(S)-(2-cyclopropylvinyl)-4-(trifluoromethyl)-3,4-dihydro-1H-quinazolin-2-one

Description:

(E)-6-Chloro-4(S)-(2-cyclopropylvinyl)-4-(trifluoromethyl)-3,4-dihydro-1H-quinazolin-2-one is a synthetic organic compound characterized by its complex structure, which includes a quinazolinone core. This compound features a chloro substituent and a trifluoromethyl group, which can significantly influence its chemical reactivity and biological activity. The presence of the cyclopropylvinyl group adds to its structural diversity, potentially affecting its interaction with biological targets. As a member of the quinazolinone family, it may exhibit various pharmacological properties, making it of interest in medicinal chemistry. The stereochemistry indicated by the (S) configuration suggests specific spatial arrangements that can impact its biological efficacy and binding interactions. Additionally, the trifluoromethyl group is known for enhancing lipophilicity and metabolic stability, which can be advantageous in drug development. Overall, this compound's unique characteristics make it a subject of interest for further research in pharmaceutical applications and chemical synthesis.

Formula: C₁₄H₁₂ClF₃N₂O

InChI: InChI=1/C14H12ClF3N2O/c15-9-3-4-11-10(7-9)13(14(16,17)18,20-12(21)19-11)6-5-8-1-2-8/h3-8H,1-2H2,(H2,19,20,21)/b6-5+/t13-/m0/s1

Synonyms:

• Dpc-083
• (4S)-6-chloro-4-[(E)-2-cyclopropylethenyl]-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

DPC 083-d4

Controlled Product

CAS: 214287-99-7

Formula: C₁₄D₄H₈ClF₃N₂O

Color and Shape: Neat

Molecular weight: 320.731

Ref: TR-D585492

DPC 083

Controlled Product

CAS: 214287-99-7

Applications DPC 083 is a novel anti-HIV drug used in the treatment of the affliction. Used as a non-nucleoside reverse-transcriptase inhibitor, it helps control the replication of genetic material. It is an analog of efavirenz (E425000).
References Sorbera, L. et al.: Drugs Future., 27, 331 (2002); Yuan, H. et al.: Chem. Eur. J., 19, 15856 (2013);

Formula: C₁₄H₁₂ClF₃NO

Color and Shape: Neat

Molecular weight: 316.71

Ref: TR-D585490

BMS-561390

CAS: 214287-99-7

BMS-561390, a reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection.

Formula: C₁₄H₁₂ClF₃N₂O

Color and Shape: Solid

Molecular weight: 316.71

Ref: TM-T26851