CAS 2143452-20-2

TSHR antagonist S37a

Description:

TSHR antagonist S37a, identified by its CAS number 2143452-20-2, is a chemical compound that functions as an antagonist of the thyroid-stimulating hormone receptor (TSHR). This compound is primarily studied for its potential therapeutic applications in conditions related to thyroid hormone regulation, such as hyperthyroidism and certain types of thyroid cancer. Characteristically, TSHR antagonists like S37a work by inhibiting the action of thyroid-stimulating hormone (TSH), thereby reducing the stimulation of thyroid hormone production. This can lead to a decrease in metabolic activity associated with excess thyroid hormones. The compound's structure typically includes specific functional groups that confer its biological activity and selectivity towards the TSH receptor. Research into S37a may also explore its pharmacokinetics, efficacy, and safety profile, which are crucial for understanding its potential use in clinical settings. As with many pharmacological agents, the development and application of TSHR antagonists are guided by ongoing studies to optimize their therapeutic benefits while minimizing side effects.

Formula: C₂₅H₂₀N₂O₃S₂

Synonyms:

• TSHR antagonist S37a,TSHR antagonist S-37a
• TSHR antagonist S37a
• 5,9-Methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione, 3,4a,5,5a,8a,9,9a,10-octahydro-7,10-diphenyl-, (4aS,5S,5aR,8aR,9R,9aS,10R)-

(4aS,5S,5aR,8aR,9R,9aS,10R)-7,10-Diphenyl-3,4a,5,5a,8a,9,9a,10-octahydro-5,9-methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione

CAS: 2143452-20-2

(4aS,5S,5aR,8aR,9R,9aS,10R)-7,10-Diphenyl-3,4a,5,5a,8a,9,9a,10-octahydro-5,9-methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione

Purity: 99%

Molecular weight: 460.58g/mol

Ref: 54-OR1074542

Tshr antagonist S37a

CAS: 2143452-20-2

Tshr antagonist S37a is an analog of oxytocin that acts as a kinase inhibitor. It has been shown to be effective against cancer cells in Chinese hamster ovary cells and human tumor cell lines. Tshr antagonist S37a inhibits the cell cycle and promotes apoptosis in cancer cells, making it a potential anticancer agent. Additionally, this protein inhibitor has been detected in urine samples from cancer patients, suggesting its potential as a diagnostic tool for cancer detection.

Formula: C₂₅H₁₉N₂O₃S₂

Purity: Min. 95%

Molecular weight: 459.6 g/mol

Ref: 3D-TKD45220

TSHR antagonist S37a

CAS: 2143452-20-2

TSHR antagonist S37a is a selective, orally bioavailable TSHR antagonist that inhibits TSH-induced cAMP in TSHR-expressing HEK 293 cells.

Formula: C₂₅H₂₀N₂O₃S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 460.57

Ref: TM-T13217