CAS 21462-56-6

Thyroxine glucuronide

Description:

Thyroxine glucuronide is a conjugated form of thyroxine, a thyroid hormone, which plays a crucial role in regulating metabolism, growth, and development in the body. The glucuronide form is created through the process of glucuronidation, where a glucuronic acid molecule is attached to thyroxine, enhancing its solubility and facilitating its excretion from the body. This compound is typically found in biological fluids and is significant in pharmacokinetics, as it reflects the metabolism of thyroxine. Thyroxine glucuronide is characterized by its relatively high polarity due to the presence of the glucuronic acid moiety, which influences its interaction with biological systems and its elimination pathways. Its presence can be indicative of thyroid function and is often studied in the context of thyroid disorders or hormone replacement therapies. Analytical techniques such as liquid chromatography-mass spectrometry (LC-MS) are commonly employed to detect and quantify this compound in various biological samples.

Formula: C₂₁H₁₉I₄NO₁₀

InChI: InChI=1S/C21H19I4NO10/c22-8-1-6(3-12(26)19(30)31)2-9(23)16(8)34-7-4-10(24)17(11(25)5-7)35-21-15(29)13(27)14(28)18(36-21)20(32)33/h1-2,4-5,12-15,18,21,27-29H,3,26H2,(H,30,31)(H,32,33)/t12-,13-,14-,15+,18-,21+/m0/s1

InChI key: InChIKey=RGHRJBIKIYUHEV-OBOXGAGSSA-N

SMILES: O([C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O)C2=C(I)C=C(OC3=C(I)C=C(C[C@@H](C(O)=O)N)C=C3I)C=C2I

Synonyms:

• Glucopyranosiduronic acid, 4-[4-(L-2-amino-2-carboxyethyl)-2,6-diiodophenoxy]-2,6-diiodophenyl, β-D-
• Thyroxine glucuronide
• 4-[4-[(2S)-2-Amino-2-carboxyethyl]-2,6-diiodophenoxy]-2,6-diiodophenyl β-D-glucopyranosiduronic acid
• β-D-Glucopyranosiduronic acid, 4-[4-[(2S)-2-amino-2-carboxyethyl]-2,6-diiodophenoxy]-2,6-diiodophenyl
• β-D-Glucopyranosiduronic acid, 4-[4-(2-amino-2-carboxyethyl)-2,6-diiodophenoxy]-2,6-diiodophenyl, (S)-

Levothyroxine Phenolic Glucuronide Disodium Salt

CAS: 21462-56-6

Formula: C₂₁H₁₇I₄NO₁₀·2Na

Molecular weight: 950.98 2*22.99

Ref: 4Z-L-4603

Thyroxine 4’-O-β-D-Glucuronide

CAS: 21462-56-6

Applications Thyroxine 4-O-β-D-Glucuronide is a major metabolite and glucuronide conjugate of Thyroxine (T425600) formed via the glucuronidation of the phenyl hydroxyl group.
References Tong, Z. et al.: Drug Metab. Dispos., 35, 2203 (2007); West, C.D. et al.: J. Clin. INvest., 42, 1134 (1963);

Formula: C₂₁H₁₉I₄NO₁₀

Color and Shape: Neat

Molecular weight: 952.99

Ref: TR-T425630

Thyroxine-13C6 4'-O-β-D-Glucuronide Disodium Salt

Controlled Product

CAS: 21462-56-6

Formula: C₁₅₁₃C₆H₁₇I₄NNa₂O₁₀

Color and Shape: Neat

Molecular weight: 1002.91

Ref: TR-T425632

Thyroxine glucuronide

CAS: 21462-56-6

Thyroxine glucuronide is a diphenyl ether that has been detected in the urine of humans and animals as a result of the metabolism of thyroxine (T4). The compound is excreted in the urine unchanged, or after being hydrolyzed to form either 3,5-diiodothyronine glucuronide or 3-iodothyronamine glucuronide. It is also excreted in wastewater from on-line chemical processing. The compound can be detected by methods such as clinical chemistry, chromatography, and immunoassays. High values are found in Sprague-Dawley rats that have been treated with multidrugs or multidrug resistance-associated protein.

Formula: C₂₁H₁₉I₄NO₁₀

Purity: Min. 95%

Molecular weight: 952.99 g/mol

Ref: 3D-FT32499