CAS 21462-56-6: Thyroxine glucuronide

Description: Thyroxine glucuronide is a conjugated form of thyroxine, a thyroid hormone, which plays a crucial role in regulating metabolism, growth, and development in the body. The glucuronide form is created through the process of glucuronidation, where a glucuronic acid molecule is attached to thyroxine, enhancing its solubility and facilitating its excretion from the body. This compound is typically found in biological fluids and is significant in pharmacokinetics, as it reflects the metabolism of thyroxine. Thyroxine glucuronide is characterized by its relatively high polarity due to the presence of the glucuronic acid moiety, which influences its interaction with biological systems and its elimination pathways. Its presence can be indicative of thyroid function and is often studied in the context of thyroid disorders or hormone replacement therapies. Analytical techniques such as liquid chromatography-mass spectrometry (LC-MS) are commonly employed to detect and quantify this compound in various biological samples.

Formula: C₂₁H₁₉I₄NO₁₀

InChI: InChI=1S/C21H19I4NO10/c22-8-1-6(3-12(26)19(30)31)2-9(23)16(8)34-7-4-10(24)17(11(25)5-7)35-21-15(29)13(27)14(28)18(36-21)20(32)33/h1-2,4-5,12-15,18,21,27-29H,3,26H2,(H,30,31)(H,32,33)/t12-,13-,14-,15+,18-,21+/m0/s1

InChI key: InChIKey=RGHRJBIKIYUHEV-OBOXGAGSSA-N

SMILES: O=C(O)C1OC(OC2=C(I)C=C(OC3=C(I)C=C(C=C3I)CC(N)C(=O)O)C=C2I)C(O)C(O)C1O

Synonyms:

• Glucopyranosiduronic acid, 4-[4-(L-2-amino-2-carboxyethyl)-2,6-diiodophenoxy]-2,6-diiodophenyl, β-D-
• Thyroxine glucuronide
• 4-[4-[(2S)-2-Amino-2-carboxyethyl]-2,6-diiodophenoxy]-2,6-diiodophenyl β-D-glucopyranosiduronic acid
• β-D-Glucopyranosiduronic acid, 4-[4-[(2S)-2-amino-2-carboxyethyl]-2,6-diiodophenoxy]-2,6-diiodophenyl
• β-D-Glucopyranosiduronic acid, 4-[4-(2-amino-2-carboxyethyl)-2,6-diiodophenoxy]-2,6-diiodophenyl, (S)-

Levothyroxine phenolic glucuronide

CAS: 21462-56-6

• Formula: C₂₁H₁₉I₄NO₁₀
• Molecular weight: 953.00

Thyroxine 4’-O-Beta-D-Glucuronide

CAS: 21462-56-6

Applications Thyroxine 4-O-β-D-Glucuronide is a major metabolite and glucuronide conjugate of Thyroxine (T425600) formed via …

• Formula: C₂₁H₁₉I₄NO₁₀
• Color and Shape: Off-White
• Molecular weight: 952.99

Thyroxine-13C6 4’-O-Beta-D-Glucuronide Disodium Salt

CAS: 21462-56-6

• Formula: C₁₅₁₃C₆H₁₇I₄NNa₂O₁₀
• Color and Shape: Neat
• Molecular weight: 1002.91

Thyroxine glucuronide

CAS: 21462-56-6

Thyroxine glucuronide is a diphenyl ether that has been detected in the urine of humans …

• Formula: C₂₁H₁₉I₄NO₁₀
• Purity: Min. 95%
• Molecular weight: 952.99 g/mol